Deshmukh Sameer, Bhalchandra (2012) Invitro Cytotoxic and Cytoprotective Activity of Silibinin and Genistein on Breast and Colon Cell Lines. Masters thesis, J K K Nattraja College of Pharmacy, Komarapalayam.
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Abstract
Cancer known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. Not all tumors are cancerous. Benign tumors do not grow uncontrollably, do not invade neighboring tissues, and do not spread throughout the body to evaluate the in-vitro cytotoxic and cytoprotective activity of silibinin and genistein on breast and colon cell lines. It was found that there was significant decrease in the viability of the cells, when the cells are treated with the two compounds silibinin and genistein. The compounds has shown marked cytotoxicity in single and in combination treatments. The compounds has shown a significant results in combination treatment on the breast and colon cancer cell lines comparison with the single treatment. The antioxidant nature of genistein has confirmed by in-vitro antioxidant studies which showed good results at different concentrarions and also the silibinin has also shown good cytoprotective activity in-vitro in single and in combination treatments.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Invitro Cytotoxic ; Cytoprotective ; Silibinin ; Genistein ; Breast; Colon Cell Lines. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Jul 2017 07:17 |
| Last Modified: | 01 Feb 2018 16:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1963 |
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