Gokul, K (2022) Comparative study on Outcomes of Myringoplasty With and Without Platelet Rich Plasma. Masters thesis, Chengalpattu Medical College, Chengalpattu.
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Abstract
INTRODUCTION: Chronic suppurative otitis media is defined as chronic inflammation of the mucoperiosteal lining of the middle ear cleft. It is associated with a persistent or intermittent infected discharge through non intact tympanic membrane. Chronic otitis media (COM) is the term that equates with classic term “chronic suppurative otitis media” which is no longer advocated as there is no pus in all case of chronic otitis media. They are now divided into active COM where there is production of pus and inactive COM where there is no pus but can become active at times. AIMS AND OBJECTIVES: 1. To compare the success rate of myringoplasty with and without platelet rich plasma in inactive cases of chronic otitis media with central perforation, with a follow up period of 2 months. 2. To study the efficiency of use of autologous platelet rich plasma in closure of tympanic membrane perforation during myringoplasty by ● Preventing the graft displacement. ● Promoting quicker healing. ● Improving the overall outcome. MATERIALS AND METHODS: DESIGN OF STUDY: Randomized controlled trial. DURATION OF STUDY: 12 months. PERIOD OF THE STUDY: April 2020 to March 2021. STUDY CENTRE: Department of Otorhinolaryngology, Chengalpattu Medical College& Hospital, Chengalpattu. STUDY POPULATION: Study was conducted in patients who underwent myringoplasty admitted at Chengalpattu Medical College Hospital, Chengalpattu during the study period. SAMPLE SIZE: 80 subjects. CRITERIA INCLUSION CRITERIA: • Chronic otitis media inactive mucosal disease. • Patients greater than 18 years of age. • Central perforation. • Dry ear without discharge for at least 6 to 8 weeks. • Hearing loss less than 40dB. • Middle ear mucosa normal. EXCLUSION CRITERIA: • Patients less than 18 years of age. • Active ear disease. • Total perforation. • Marginal perforation. • Tympanosclerosis. • Cholesteatoma. • Otosclerosis. • Atopic ear conditions. • Middle ear mucosa congested or polypoidal. • Other systemic illness like autoimmune diseases and active neoplastic diseases. METHODOLOGY: This study was conducted for 80 patients of chronic suppurative otitis media in our institution from April 2020 to March 2021. The study only included patients who met the above criteria. Pre-operative information was gathered. After explaining the procedure to all of the patients, informed consent was obtained. Complete blood count, bleeding and clotting time, ECG and chest x-ray, HIV testing, and hepatitis B surface antigen test were among the tests performed prior to surgery. In our anaesthesia department, all patients had an anaesthetic workup. The patients were randomly divided into two groups. CONCLUSION: When autologous platelet rich plasma is administered in myringoplasty, it accelerates epithelialization over the graft, resulting in faster graft uptake. Because it has a high concentration of platelets, it reduces graft displacement. Since platelet rich plasma is derived from the patient's own blood, it has no risk of transmitting HIV, Hepatitis B, or other blood-borne infections from others. Since it is cost - effective and easy to produce, it should be utilized during myringoplasty to improve the success rate. This is to conclude from our study that there is a definite benefit by using PRP in myringoplasty. As the PRP can be easily prepared, myringoplasty with PRP can be routinely performed. The overall graft uptake rate appeared to be better with myringoplasty with PRP with significant results.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221914551 |
| Uncontrolled Keywords: | Myringoplasty, With and Without Platelet Rich Plasma, Comparative study. |
| Subjects: | MEDICAL > Otolaryngology > MEDICAL > Otolaryngology |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Apr 2022 16:21 |
| Last Modified: | 17 Dec 2023 13:09 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19383 |
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