Kiruthiga, G (2012) A Study on Virana Silethumam. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The aim of the study is to evaluate the safety and efficacy of Pancha vakraga chooranam in the management of Virana Silethumam. The Siddhars with their tremendous foreseeing and unfathomable knowledge have clearly mentioned the symptomatology, etiology and treatment of Virana silethumam. For the clinical study, 40 cases were selected with 33 cases treated in OPD and 7 cases in IPD of Ayothidass Pandithar Hospital of National Institute of Siddha, Chennai. Clinical diagnosis was done by means of Siddha and Modern Methodology. The trial subjects were treated with Pancha vakraga Chooranam with twice daily dosing according to the age group. Based on the reporting patients, the improvement in the condition of the patients was observed from the second day itself. Within 4 days, patient showed good relief in symptoms. Observations made during the clinical study showed that the trial drug was clinically effective. In clinical observation, it was found that 73% of the patients showed good relief in signs and symptoms. Further , there was no development of any adverse drug reactions in the pediatric population. Biochemical analysis showed absence of heavy/toxic metals laying a stress on the safety of the drug. Further more, the acute and long term toxicity studies confirmed the safety of the drug and dosing among pediatric population. In GC-MS Analysis, Eugenol constituted about 90% of the drug constituents. Eugenol, a well-known phenolic derivative is proved to have Anti-inflammatory, Anti-microbial activity and influences the efficacy of the prepared drug. Pharmacologically, Pancha vakraga chooranam had significant analgesic, anti-pyretic and anti-inflammatory action enough to produce clinical effects. CONCLUSION: Clinical trial with Pancha vakraga chooranam showed remarkably good results in the management of Virana silethumam without producing any adverse drug effects. A safe herbal formulation that can be prepared readymade with kitchen condiments is clinically efficacious in treating even acute inflammatory conditions like acute pharyngo - tonsillitis. The drug can be safely administered to small infants in the event of recurrent episodes due to climatic changes. Palatability and easy administration of three times to four times daily dosing will be influenced with the use of the honey as adjuvant/vehicle. Thus, it is concluded that in a developing countries like ours, the treatment with Pancha vakraga chooranam will prove safe, efficacious and easily available with cost effective ingredients for the welfare of pediatric population.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.32092702 |
| Uncontrolled Keywords: | Efficacy of Herbal Siddha Drug, Panchavakraga Chooranam, Virana Silethumam, Acute Pharyngo-Tonsillitis. |
| Subjects: | AYUSH > Kuzhanthai Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Aug 2020 17:23 |
| Last Modified: | 03 Aug 2020 17:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12743 |
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