Shyjumon George, (2019) To assess the diagnostic accuracy of CT in differentiating the varying aetiologies causing diffuse disease of the peritoneum with histopathology co-relation. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: 1. To assess the diagnostic accuracy of CT in differentiating the various etiologies of diffuse peritoneal disease. 2. To estimate the spectrum and identify the differentiating features of varying etiologies of diffuse peritoneal disease METHODS: All patients with peritoneal disease who had abdominal CT and subsequently underwent omental biopsies (both surgical and ultrasound guided) from 1st January 2016 to 31st December 2017, a total of 136 patients, were included in our study. The imaging findings were reviewed in PACS by 2 radiologists independently, who were blinded to the patient demographics, the clinical findings and the histopathologic results. The CT findings were assessed under various specific headings to describe peritoneal, mesenteric or omental involvement and few general features like ascites, lymphadenopathy and splenomegaly. The CT findings were then compared and evaluated with histopathology as the gold standard. The baseline continuous variables were compared between the benign and malignant using independent –“t” test, and the categorical variables were compared using chi-square statistics. The significant predictors at 5% level were chosen and a logistic regression was performed mutually adjusted for the predictors selected. RESULTS: We found that higher age, increasing omental thickness, omental caking, larger mesenteric/peritoneal nodules, visceral scalloping, free ascites, serosal involvement and bilaterality of pleural effusion were associated with malignant etiology while mesenteric thickening/stranding, mesenteric adenopathy, necrotic lymph nodes, splenomegaly and higher attenuation (>20HU) of ascitic fluid were more associated with benign etiology. Overall, CT had a high diagnostic accuracy for differentiating benign and malignant etiologies of diffuse peritoneal disease with good sensitivity and specificity with substantial interobserver agreement.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.201718055 |
| Uncontrolled Keywords: | Omental biopsy, diffuse peritoneal disease, CT features, histopathology. |
| Subjects: | MEDICAL > Radio Diagnosis |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Aug 2019 23:33 |
| Last Modified: | 21 Aug 2019 23:41 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/11060 |
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