Ashokkumar, N (2018) Green Synthesis, Characterization, In-Silico Molecular Docking study and In-Vitro Anti-Cancer Activity of 1,2,3-Triazolyl Dihydropyrimidine-2-Thione Hybrids. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
The present work deals with the green synthesis, characterization, molecular docking and anti-cancer activity of new series of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids. The study comprises of: Designed the lead molecule of and 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids assessed ADMET property. Synthesis of the title compounds by appropriate methods. Determination of physical properties such as solubility, melting point and TLC. Characterise the structures of synthesized compounds by IR, 1HNMR and Mass spectra. Evaluation of the synthesized compounds for their in-vitro anti-cancer activity. • The compounds were synthesized by reaction between 1,2,3-triazolyl chalcone and aromatic aldehydes in the presence of 50% aqueous sodium hydroxide grinding 4-7 minutes. Then the above product treated with thiourea 10% potassium hydroxide and water reflux to form 1,2,3- triazolyl dihydropyrimidine-2-thione hybrids. • The method had been optimized to synthesis for the synthetic compounds. • The compounds were synthesized by appropriate method. • The synthesized compounds were purified by TLC. • The synthesized compounds were confirmed by FT-IR, 1H NMR, MASS Spectroscopy. • The IR data showed relevant bands for the functional groups present in the synthesized compounds. • The 1H NMR also showed relevant proton peaks for all the synthesized compounds. • The molecular weights of the compounds were done by MASS Spectrocopy. • All spectral data coincides with the assigned structure of synthesized compounds. • The synthesized compounds are analyzed with various steps of molecular docking studies and finally concluded for the activity. • The synthesized compounds were screened for in-vitro anti-cancer activity. In-vitro anti-cancer activity: All the synthesized compounds exposed anti-cancer activity by MTT assay method. The synthesized compounds HYBRID-5a, HYBRID-5c are show good anti- cancer activity. HYBRID-5b, HYBRID-5d, HYBRID-5e, shown very poor anti-cancer activity.
| Item Type: | Thesis (Masters) |
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| Additional Information: | REG.NO.261615751 |
| Uncontrolled Keywords: | In-Vitro Anti-Cancer Activity ; 1,2,3-Triazolyl Dihydropyrimidine-2-Thione Hybrids ; Green Synthesis ; Characterization ; In-Silico Molecular Docking study. |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Jun 2019 03:48 |
| Last Modified: | 28 Jun 2019 03:48 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10640 |
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