Siva Josyaa, S (2018) An Open clinical study of Siddha drugs Thirutharakchatha Chooranam (Internal) and Aruganver Thylam (External) in the treatment of Viyagulaunmatham (Depression). Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The disease Viyagula Unmatham was taken for the clinical study with Thirutharakchatha chooranam as internal medicine and Aruganver Thylam for external application for oil bath 2 times per week, for the clinical study, 30 cases were selected based on the approved protocol. The raw drugs were authenticated by the competent authority Medicinal Botany and Gunapadam dept, Botanical Authentication Certificate no: NISMB3382018. This study has been approved by IEC of NIS [Date of IEC Approval& its number: NIS/IEC/2016/11-12/14.10.2016]. The study is safely executed on patients and there were no adverse drug reactions noted during the study period and further registered Clinical Trail Registry of India [REG. NO. CTRI/2018/04/013421]. Out of 30 cases treated at OPD, of Ayothidoss Pandithar Hospital of National Institute of Siddha, Chennai-47. Randomly selected 15 cases (2, 5, 7, 8, 10, 13, 14, 18, 19, 21, 23, 26, 27, 29, 30) were received Yogam therapy. The detailed study on Viyagula unmatham with reference to its aetiology, pathogenesis, investigations, clinical features, diagnosis and treatment with trial drugs was done. The results were observed by HAM-D score. Among the 30 cases treated, 33.3% cases had shown good improvement, 53.3 % cases had shown moderate improvement and 13.3% cases had shown mild improvement. Randomised selected 15 patients were received additionally Yogam therapy. This revealed 80% of the patients showed more than 50% improvement. Combined trial medicine and yogam therapy shown more significant improvements. CONCLUSION: The present clinical study confirms the efficacy of the trial drug Thirutharakchatha chooranam (internal medicine) and Aruganver thylam (external medicine) which is Siddha poly herbal formulation. It was found to be better resulting on Viyagula unmatham patients in reducing clinical symptoms like depressive mood, loss of sleep and appetite, weight loss, lack of concentration, anhedonia, suicidal thoughts etc. The literature evidence for this drug Agathiyar Vaithiya Ratna Surukam page no 45, Publication of Tanjavur Magaraja Sarabojini Saraswathy Mahal Noolagam. The quantitative outcome of HAM-D score shows significant reduction between before and after treatment. The qualitative outcome shows there is 33.3% of cases had shown good improvement and the rest 53.3% of cases had shown moderate improvement and 13.3% of cases mild improvement. Further the Yogam had shown more impressive result of reduction of symptoms of Viyagula unmatham (Depression). It shows the better improvement more than 50% was 26 (86.6%) patients. According to this result it could be observed that yogam therapy is further given as support to improve the condition of Viyagula unmatham (Depression). The Modern Medical concept of Anxiety related somatic complaints or Culture bound syndrome also has to be proven. The clinical trial conducted in selected patients was satisfactory and the results were encouraging. However, a study with large number of patients is required to find out the ideal dose response. The costs of the trial medicines are comparatively low. The trail medicines are cost effective. From the above results, the trial drugs “Thirutharakchatha chooranam” (Internal Medicine) and “Aruganver Thylam” (External Medicine) are responded well in the treatment of Viyagula unmatham.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg.No.321513205) |
| Uncontrolled Keywords: | Open clinical study ; Siddha drugs ; Thirutharakchatha Chooranam ; Aruganver Thylam ; treatment ; Viyagulaunmatham ; Depression. |
| Subjects: | AYUSH > Sirappu Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Dec 2018 11:12 |
| Last Modified: | 29 Dec 2018 11:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10258 |
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