Estimation of salivary levels of heat shock proteins 60 in cardiovascular diseased patients with chronic periodontitis

Archana Meenakshi, A (2012) Estimation of salivary levels of heat shock proteins 60 in cardiovascular diseased patients with chronic periodontitis. Masters thesis, Ragas Dental College and Hospital, Chennai.


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BACKGROUND: The association between periodontal disease and cardiovascular disease have been reported in various earlier studies, but the pathological mechanism behind the relation is still inconclusive. Recently phylogenetically conserved nature of Heat shock proteins 60 (Hsps60) has led to the proposition that they may provide a link between Periodontal disease and Cardiovascular disease. Saliva is a non invasive diagnostic medium that has been used to assess several inflammatory disorders including Periodontal disease This study aims at assessing the levels of Heat shock protein 60 (Hsp60) in systemic health and cardiovascular diseased groups with Chronic Periodontitis. MATERIALS AND METHODS: Salivary samples were collected from 49 subjects and they were divided into two groups, Group A-23 Subjects in systemic health; Group B-26 patients with Cardiovascular disease (with chronic periodontitis). Hsp60 levels in both the groups were estimated by sandwich Enzyme Linked Immuno Sorbent Assay (ELISA). Statistical analysis was performed using the student ‘T ‘test and Pearson’s correlation. RESULTS: There was no significant difference in the salivary Hsp60 levels between systemically healthy and cardiovascular diseased patients with periodontitis (p = 0.3244). CONCLUSION: The preliminary results indicate that Salivary Hsp60 levels may not be a potential marker for CVD but a larger sample size would be necessary to confirm the hypothesis.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Hsp60 ; Periodontitis ; Atherosclerosis ; ELISA.
Subjects: DENTAL > Periodontology
Depositing User: Subramani R
Date Deposited: 26 Oct 2018 03:08
Last Modified: 26 Oct 2018 03:08

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