Comparative study in the management of Bacterial Vaginosis Metronidazole vs Lactobacillus.

Narmadha, S (2011) Comparative study in the management of Bacterial Vaginosis Metronidazole vs Lactobacillus. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Bacterial vaginosis is due to imbalance in the normal bacterial flora of vagina. Bacterial vaginosis is a polymicrobial syndrome involving the replacement of the normal vaginal lactobacillus by variety of anaerobic bacteriae and mycoplasmas. Bacterial vaginosis is the commonest cause of vaginal discharge ( 48% ) in women with significant morbidity.1 If untreated , patients are more prone for ascending endometrial infections, preterm delivery and increased risk of acquisition of Herpes genitalis, Gonorrhoea and HIV infections. Most of the cases are asymptomatic and recurrences are common even in treated cases. Recurrence of the disease , unknown incubation period , adverse outcomes on pregnancy and complications like pelvic inflammatory disease necessitated the need to find an alternative drug , in this emerging antibiotic resistance period. In this background we planned to conduct this study to compare the efficacy of Metronidazole , the commonly used drug and Lactobacillus , a Probiotic alternative drug. AIM & OBJECTIVES : 1. To analyse the epidemiological pattern of the disease among the study population. 2. To compare the efficacy of metronidazole and lactobacillus in the management of bacterial vaginosis. 3 . To evaluate safety, adverse effects, compliance of metronidazole and lactobacillus. 4. To monitor the recurrence of Bacterial vaginosis following each therapeutic modality. CONCLUSION 1. Bacterial vaginosis was seen commonly in the age group of 24 – 40 years. * Menstrual cycle irregularities had no association with prevalence. BV was seen in both married and unmarried as well as those who never had sexual intercourse. But the incidence in unmarried & those who never had sexual intercourse is minimal. * The earlier age at marriage was directly proportionate to incidence of BV. * 77 %, Majority had mono partners, 17 % had multiple sexual partners and 6% denied sexual exposure. * The mode of delivery had no significant association. Number of deliveries was directly proportionate to acquisition of BV. * Moderate to profuse genital discharge was the commonest observed finding. * In saline mount 90 % showed clue cells positivity. Whiff test was positive in 80% , Vaginal pH was > 5 in all the patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Management of Bacterial Vaginosis ; Metronidazole ; Lactobacillus ; Comparative study.
Subjects: MEDICAL > Dermatology Venereology Leprosy.
Depositing User: Subramani R
Date Deposited: 05 Jul 2017 06:10
Last Modified: 05 Jul 2017 09:18

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