Formulation and Evaluation of Chitosan Nanoparticles.

Balaji, R (2014) Formulation and Evaluation of Chitosan Nanoparticles. Masters thesis, Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam, Tamil Nadu, India.


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Nanoparticulate drug delivery systems (DDS) have attracted a lot of attention because of their size-dependent properties. Among the array of nanoparticles being currently investigated by pharmaceutical scientists, lipid nanoparticles have taken the lead because of obvious advantages of higher degree of biocompatibility and versatility. These systems are commercially viable to formulate pharmaceuticals for topical, oral, pulmonary or parenteral delivery. The co-administration of lipids with drugs can also impact their absorption pathway although most orally administered compounds gain access to the systemic circulation via the portal vein, some highly lipophilic drugs are transported directly to the systemic circulation via intestinal lymphatic’s, which improves oral bioavailability of poorly water soluble API like lovastatin. The solid lipid nanoparticles of lovastatin formulation can be effective in treatment of lowering cholesterol and the drug was released from the formulation in a constant manner for the desired period of time. The solid lipid nanoparticles of lovastatin evaluated here has potential in reduction of cholesterol, for the reason that improved solubility can improve the bioavailability of the poorly soluble drug lovastatin and considered to be promising for prolonging the release of drug compared with other conventional formulations.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Formulation; Evaluation; Chitosan Nanoparticles
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 05 Jul 2017 06:12
Last Modified: 05 Jul 2017 06:12

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