Cutaneous Manifestations of Systemic Lupus Erythematosus.

Nithya Gayathridevi, D (2010) Cutaneous Manifestations of Systemic Lupus Erythematosus. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : HIPPOCRATES, ROGERIUS, PARACELSUS, MANARDI, AMATUS LUSITANUS, SENNERT etc. are some of the early renowned Physicians who have described "LUPUS" which is derived from the Latin word which means "WOLF" depicting its nature of destruction. The ulcerated skin lesions typical of this disease signify this feature as it "bites, eats away and destroys". Lupus erythematosus (LE) was identified only as a cutaneous disease, until a century ago when emphasis was transferred from the integument to include visceral manifestations. At the beginning of this century blood vessels and connective tissues distributed throughout the body came to be implicated in the pathogenesis, which lead to the concept of "multisystem malady”. In 1942, KLEMPERER et al were struck by the many, morphological features that were common to diseases as distinct as Lupus erythematosus, Scleroderma, Dermatomyositis, Rheumatoid Arthritis, Acute Rheumatic Fever and Poly Arteritis Nodosa and classified them as "Collagen disease" or "Collagenosis". The discovery of auto antibodies to various cellular components of different tissue in these diseases has of late given place to the concept of "autoimmune diseases". AIM OF THE STUDY : 1. To study the incidence of SLE in Government General Hospital, Chennai during the period between August 2007 to September 2009. 2. To study the incidence of various cutaneous spectrum of SLE. 3. To study the age and sex incidence. 4. To study the commonest site of lesions in various spectrum. 5. To study the precipitating and exacerbating factors. 6. To study the various mucocutaneous presentations. 7. To study relevant laboratory abnormalities. 8. To study the associated disorders. 9. To study the histopathological features and Immunofluorescence pattern. CONCLUSIONS : * The incidence of SLE during the period of August 2007 to September 2008 is 0.08%. * ACLE is the commonest spectrum followed by CCLE and SCLE. * Commonest age group falls between 20 to 30 years. Youngest age documented was 15 years and oldest age was 50 years. * Female preponderance was seen in all types of spectrum. * Sunlight is the commonest among the precipitating and exacerbating factor followed by infections, physical/mental stress, drugs, pregnancy and menstruation. * Familial history of other associated autoimmune disease states that, genetic back ground is an important contributing factor. * Diffuse hair loss and photosensitivity are common among the cutaneous symptoms. Palatal ulcer is the most common mucosal symptoms and it is commonly associated with ACLE. Fever and arthralgia are the most common symptoms among the systemic symptoms.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Cutaneous Manifestations ; Systemic Lupus ; Erythematosus.
Subjects: MEDICAL > Dermatology Venereology & Leprosy
Depositing User: Subramani R
Date Deposited: 05 Jul 2017 04:49
Last Modified: 05 Jul 2017 09:10

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