Randomized Therapeutic trial for patients with Alopecia Areata .

Meera, G (2010) Randomized Therapeutic trial for patients with Alopecia Areata . Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : In humans, hair's main purpose revolves around its profound role in social interactions. Oliver Herford said “A hair in the head is worth two in the brush”. Given their prominence in daily dermatologic practice, hardly any dermatologist can escape having to manage patients with hair growth disorders. ALOPECIA AREATA (Abbreviation : AA) is a chronic, organ-specific autoimmune disease, probably mediated by autoreactive T cells, which affects hair follicles and sometimes the nails. Although not life threatening, the cosmetic disfigurement that leads on to significant psychological and emotional distress supports a multibillion-dollar effort to reverse this condition. Though various modalities are available for the treatment of alopecia areata, assessment of the efficacy of a treatment must be considered with care because the condition is highly unpredictable in presentation, evolution, and response to treatment. Little data exist regarding the natural evolution of the condition. Hence with this in mind the following study was carried out to see the treatment response for various modalities and chances of spontaneous resolution for this benign condition. AIMS OF STUDY : The aims of the present study was 1. To study the efficacy of various modalities of treatment & to compare them with one another. 2. To study the adverse effects of the various modalities used. CONCLUSION : 1. Significant improvement occurred in patients treated with topical minoxidil(90%), intralesional steroids(90%) and cryotherapy with liquid nitrogen(90%) than the control group(20%) treated with placebo. 2. All the three significant treatment modalities produced only transient adverse effects which did not interfere with the patient compliance. 3. Other contrasts (study groups) are not statistically significant since each group comprised of ten patients only (n=10) and this remains the limitation of our study. Therefore studies in larger groups are needed are needed for further evaluation of other groups in our study. 4. The number of patches (single/ multiple) among different study groups doesn’t influence the response outcome (P=0.26). 5. Proportion of improvement in number of patches ( single/ multiple) among atopics and the non atopics was statistically insignificant and hence there is no correlation between atopy and the number of patches and its response outcome. 6. Atopy does not appear to be a significant factor in the response to therapy in patients with alopecia areata. 7. Atopy in the form of personal and family history was the only significant association found in the present study group (20%). 8. There was no significant difference in the mean age and gender distribution among different study groups.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Alopecia Areata ; Randomized Therapeutic trial.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Jul 2017 04:44
Last Modified: 05 Jul 2017 09:09
URI: http://repository-tnmgrmu.ac.in/id/eprint/976

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