Prevalence of Helicobacter pylori infection and influence of laryngopharyngeal reflux in patients with laryngeal pathologies

Neenu, Anna Joseph (2015) Prevalence of Helicobacter pylori infection and influence of laryngopharyngeal reflux in patients with laryngeal pathologies. Masters thesis, Christian Medical College, Vellore.

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Abstract

OBJECTIVES: To study the prevalence of Helicobacter pylori in patients with laryngeal pathologies and to study the association of laryngopharyngeal reflux in laryngeal pathologies by means of Reflux Symptom Index and Reflux Finding Score. METHODS OF STUDY: All patients who presented to the ENT outpatient department with complaints of change in voice and who were scheduled for microlaryngoscopic surgery were enrolled in the study after obtaining an informed consent. Presence of laryngopharyngeal reflux in these patients was assessed by the Reflux Finding Score (RFS) and Reflux Symptom Index questionnaire. Tissue from the larynx was taken for real time PCR analysis and Giemsa staining for detection of Helicobacter pylori. RESULTS: Our study could not detect Helicobacter pylori in laryngeal pathologies by PCR analysis or by Giemsa staining method. CONCLUSION: In this study conducted on 100 patients with hoarseness and laryngeal pathologies, Helicobacter pylori was not isolated in the laryngeal tissue biopsy material suggesting that the organism had no role in the development of benign or malignant laryngeal pathology. PCR test using primers which can detect all the genes (UreA, glmM, 26kDa SSA, 16S rRNA) in H. pylori would be more specific than detecting a single gene which might possibly be missed during testing. Our study also found an association between laryngopharyngeal reflux in laryngeal pathologies, even though the association did not reach statistical significance.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Helicobacter pylori ; Laryngopharyngeal reflux ; PCR.
Subjects: MEDICAL > Otolaryngology
Depositing User: Devi S
Date Deposited: 07 Oct 2018 06:27
Last Modified: 07 Oct 2018 06:28
URI: http://repository-tnmgrmu.ac.in/id/eprint/9731

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