Sumit, Singh (2015) Human epidermal growth-factor receptor 2 (HER2) Over-expression frequency in gastric carcinoma and Its correlation with clinic-pathological findings in patients Presenting to a tertiary care center in South India. Masters thesis, Christian Medical College, Vellore.
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Abstract
BACKGROUND: Gastric cancer is the one of the leading causes of cancer related death worldwide. Epidermal growth factor receptor (EGFR) is a transmembrane receptor which is associated with cell survival, proliferation and inhibition of apoptosis. Recently there has been an increase in interest to know the association of Human Epidermal Growth Factor Receptor-2 (HER2) with gastric cancer. This study is aimed to assess the incidence of HER2 positivity in a patient cohort who have undergone surgical resection for gastric cancer in India. OBJECTIVES: 1. To determine human epidermal growth-factor receptor (HER2) protein-over expression frequency in patients operated for gastric carcinoma in an Indian population. 2. To determine the correlation of HER-2 positivity with pathological findings and other factors. Type of study: Prospective observational study. METHODS: 53 patients who underwent gastrectomy for carcinoma stomach were tested for HER2 positivity in the resected specimen. Representative tissue bits from the tumor were collected and processed. The processed tissue was tested using immunohistochemistry (IHC) on a Ventana Benchmark-XT fully automated machine. RESULTS: From the data that was collected, HER2 was positivity was seen in at least 4 of the 53 gastrectomy specimens amounting to a prevalence of 7.5%. A further 11% of the cases were equivocal for HER2 positivity and would have required additional testing (FISH, SISH) to confirm or deny HER2 positivity. Due to cost constraints, this could not be done. CONCLUSION: This study has shown the positivity of HER2 over expression among patients diagnosed with gastric cancer and underwent surgical resection to be in the range of 7.5 to 18%. Most of the literature on this topic pegs the rate between 7% - 34% and our study confirms the rate of HER2 positivity among patients with gastric carcinoma in the Indian subcontinent is similar to what is found in other parts of the world.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Adenocarcinoma ; Stomach ; HER2/neu ; Immunohistochemistry ; Gastric. |
| Subjects: | MEDICAL > General Surgery |
| Depositing User: | Devi S |
| Date Deposited: | 06 Oct 2018 06:07 |
| Last Modified: | 06 Oct 2018 06:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9678 |
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