A prospective case study of estrogen/progesterone/human epidermal growth factor 2 receptor status in breast carcinomas

Shree Vishnu Siddharth, R (2015) A prospective case study of estrogen/progesterone/human epidermal growth factor 2 receptor status in breast carcinomas. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.

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Abstract

OBJECTIVE: To correlate the receptor status in breast carcinomas with that of the staging DESIGN: A prospective case study. PLACE AND DURATION OF STUDY: Department of general surgery PSG hospitals, Coimbatore, Tamilnadu, 1 year period from November 2013 to November 2014 PATIENTS AND METHODS: 30 patients of breast cancer (10- early, 10- late and 10- metastatic) were studied. Estrogen, progesterone and HER2 receptor status was evaluated by immunohistochemistry. This was correlated with the clinical staging of the disease. RESULTS: Out of 30 cases studied the mean age was 53.6. Estrogen receptor was positive in 50%, progesterone receptor was positive in 26.67% and HER2 was positive in 70% of the study population. There were 3 patients with triple negative disease and all of them had metastatic disease. In early breast carcinoma none of the patients had poor prognostic indicator in comparison with the receptor status. CONCLUSION: This study overall reports a positive correlation between prognosis according to clinical and hormonal staging. The observation is similar in case of estrogen receptor status and correlates with the local population but grossly differs in progesterone receptors which is significantly low in this study. 70% of the population over expressed HER2 which is unusual.

Item Type: Thesis (Masters)
Uncontrolled Keywords: estrogen ; progesterone ; human epidermal growth factor ; 2 receptor status ; breast carcinomas.
Subjects: MEDICAL > General Surgery
Depositing User: Devi S
Date Deposited: 06 Oct 2018 04:27
Last Modified: 06 Oct 2018 04:27
URI: http://repository-tnmgrmu.ac.in/id/eprint/9674

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