Formulation and In Vitro Evaluation Studies on Oral Floatin Matrix Tablets of Ritonavir

Kannedhara, Gopala Rao (2014) Formulation and In Vitro Evaluation Studies on Oral Floatin Matrix Tablets of Ritonavir. Masters thesis, College of Pharmacy, J K K Munirajah Medical Research Foundation, Komarapalayam.


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The oral drug administration has been the predominant route for drug delivery due to the ease of administration, patient convenience and flexibility in formulations. However, it is a well accepted fact today that drug absorption throughout the GI tract is not uniform. Using currently utilized release technology, oral drug delivery for 12 or even 24 hours is possible for many drugs that are absorbed uniformly from GI tract. Nevertheless this approach is not suitable for a variety of important drugs characterized by narrow absorption window in the upper part of GI tract i.e. stomach and small intestine. From the above study it can be concluded that promising controlled release by gastro retentive floating tablets of Ritonavir was developed using different ratios of HPMC K4M, K15M and K100M The floating tablet of Ritonavir was capable of maintaining plasma drug concentration through 12 hrs. The formulation F7 was selected as an optimized formulation because it gave the best result in terms of the required in-vitro buoyancy study, good floating integrity and drug release in sustained release manner. The release profile of the optimized formula, fitted best to Zero order kinetics with R2 value of 0.999. As the n value for the Korsmeyer-Peppas model was found to be less than 0.698, it follows Non fickian type of transport. short-term stability studies indicated no appreciable changes in the drug content and In-vitro drug release rates of formulation F7.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Formulation ; In Vitro ; Evaluation ; Oral Floatin Matrix Tablets ; Ritonavir.
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 05 Jul 2017 04:03
Last Modified: 16 May 2018 01:10

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