Neuroprotective role of Alpha Lipoic Acid on Oxidative Stress Induced by acrylamide in Rat Brain

26083742, - (2010) Neuroprotective role of Alpha Lipoic Acid on Oxidative Stress Induced by acrylamide in Rat Brain. Masters thesis, Vel’s College of Pharmacy, Chennai.

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Abstract

Our study is an effort to evaluate the neuroprotective effect of ALA by studying the biochemical parameter such as enzymatic and non enzymatic antioxidant, GSH, LPO and total lipid content as will as histopatholocial Alteration observed in case of Acrylamide induced rat brain. The out come of our investigation is summarized as below The level of SGPT, SGOT and LDH is increased in ACR induced rat when as the levels are reduced in ALA treated rats enzyme antioxidant (SOD, GPX) and non antioxidant (GSH, GR) was found to be declined in case of acrylamide induced rats. ALA treatment challenging with acrylamide brought back to normal level by protecting the cell membrane intergrity. An elevation in the level of the MDA was observed which is an indicator of membrane lipid peroxidation in ACR induced rat and it was reversed by the supplement of the ALA. Histopatholocigal report Shows neuronal cell degeneration in ACR induced and the cell recovery is observed on ALA treatment. Thus from our study we came to concluded that OS imposed by acrylamide resulted pronounced neurotoxicity in rats. In the contrast, ALA treated rat showed normalization of the oxidative parameters. This Snapshot throws light on the fact that the ALA might be beneficial in the OS medicated neurotoxicity provoked byacrylamide. Further comprehensive studies in the neurotoxicity of acrylamide are under way.

Item Type: Thesis (Masters)
Additional Information: (Reg. No. 26083742)
Uncontrolled Keywords: Neuroprotective role ; Alpha Lipoic Acid ; Oxidative Stress ; Induced ; acrylamide ; Rat Brain.
Subjects: PHARMACY > Pharmaceutical Biotechnology
Depositing User: Subramani R
Date Deposited: 03 Oct 2018 15:53
Last Modified: 03 Oct 2018 15:53
URI: http://repository-tnmgrmu.ac.in/id/eprint/9656

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