Vakkalagadda Ravikumar, (2009) Protective Potential of Bioflavonoid: Hesperidin against Diethylnitrosamine Induced Hepatocarcinogenesis in Rats. Masters thesis, Vel’s College of Pharmacy, Chennai.
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Abstract
The present study is an effort to evaluate the protective efficacy of Hesperidin by studying the morphological and biological alteration observed in DEN induced hepatocelular carcinoma in rats. The outcome of the investigation carried out was summarized below. The liver weight and relative liver weight were found to be increased in DEN induced rats and restored upon treatment with the hesperidin indicates its protective effect. The activities of serum marker enzymes namely AST, ALT, ALP were found to be elevated within rats induced with DEN. Hesperidin treatment against DEN brought back the activities of marker enzymes to to near normal by protecting the cell membrane integrity. An enhancement in lipid peroxide levels with simultaneous depression in the levels of antioxidants was observed in rats induced with DEN. Hesperidin treatment exerted a significant free radical quenching and antioxidant strengthening effects by decreasing the lipid peroxidation with consequent improvement in antioxidant status proving to be a potent antioxidant. Histopathological observations in DEN induced and hesperidin treated rats revealed the protective nature of the extract against DEN induced hepatocellular carcinoma and further support the hepatoprotective potential of hesperidin. Administration of DEN in rats resulted in increased levels of TNF-α. These elevated levels of TNF- α were inhibited and normal levels were attained by treatment with hesperidin. The present findings explore that treatment shows promising protective effect of hesperidin and further studies are needed to understand the molecular mechanisms of the hesperidin against DEN induced liver cancer. Hence it is concluded that hesperidin as potential for further development as a therapeutic agent for liver cancer.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.26073747 |
| Uncontrolled Keywords: | Protective Potential, Bioflavonoid, Hesperidin, Diethylnitrosamine, Induced Hepatocarcinogenesis, Rats. |
| Subjects: | PHARMACY > Pharmaceutical Biotechnology |
| Depositing User: | Subramani R |
| Date Deposited: | 03 Oct 2018 15:47 |
| Last Modified: | 17 Nov 2022 17:33 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9655 |
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