Sureka, A (2017) Standardization on purification process of Manosilai (Red Orpiment). Masters thesis, National Institute of Siddha, Chennai.
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Abstract
Siddha system of medicine emphasis, before going to medicine preparation every raw drug must be purified. The concept of Shuddhi (purification) in Siddha is not only a process of purification / detoxification, but also a process to enhance the potency and efficacy of the drug. There is no scientific evidence what all the changes occur during the purification process are. The Purification method of the chosen drug had been selected from the Siddha literature “Aagathiyar vaithiya kaaviyam 1500”. The classic method of purification was said by the famous Siddhar Aagathiyar who is known for his excellence in various realm of Siddha medicine. For the purpose of study, 500gm of raw drug Manosilai was procured from renowned country drug shop in Chennai. The authentication for raw drug was obtained from siddha central research institute, Chennai- 06. Ulunthu was procured from Market and authenticated by, Botanist, Plant Anatomy Research centre, Chennai-5. Then the raw drug was divided into two equal quantities of 250gm. One of the part of the raw drug was taken and powdered well and kept as such labelled as un purified raw drug Manosilai. The other part of the raw drug Manosilai was subjected to purification procedure Manosilai is made into small pieces and make in to a bundle, The above bundle is boiled with goat’s urine by using thula appliances and then the bundle is take out and kept in black gram boiled water after that the bundle is opened and dried it. Then it was powdered and labelled as purified drug Manosilai the qualitative and quantitative analyses were done for both the samples of unpurified and purified raw drug Manosilai. The physico-chemical analysis of the purified Manosilai reveals state of better absorption in the intestine, higher stability, purity, and Water solubility. The chemical analysis shows the presence of physiologically important metals and minerals such as arsenic, copper, Calcium, Magnesium,, Carbonate and mercury. The results of ICPOES analysis indicates the presence of increased concentration of physiologically important minerals in purified Manosilai and also slightly lower limits of heavy metals such as Mercury, Lead, Arsenic and Cadmium After purification. The results of FTIR analysis show the presence of Sulfide, Alcohol, Amine, CH, and NH2 48 functional groups. The HR-SEM analysis consists of agglomerates of various shapes and sizes in reduction with increase in magnification from before to after purification. The agglomerates were found leaving pores in between which would permit the circulation of body fluid throughout the coating, when it is used as a medicine. The XRD analysis results depicts clearly that the crystalline phase is increased with increase in intensity, which indicates that purified Manosilai is attributed for better bioavailability and dissolution rate. Pesticide residue, Microbial load& aflatoxin level were quantitatively measured in the raw Manosilai the result indicated the absence of them. CONCLUSION: The following inferences are drawn based on qualitative and quantitative analysis of before and after purification of Manosilai with goat’s urine and .boiled black gram water. a. Before purification the total ash value is 4.088% w/w w After purification the total ash value reduced to 3.319 % w/w. It denotes the impurities are removed. b. Before purification the moisture content is 0.4481 % w/w. After purification the moisture content reduced to 0.2953 % w/w. It denotes that the shelf life is increased after purification. c. ICP-0ES results suggest Mercury, Arsenic and Cadmium level reduced after purification. d. Crystalline is increased which enriches better bioavailability and dissolution of the drug. Siddha system insists on Purification before using them in the pharmaceutical preparations. The present study of purification process of Manosilai the impurities is removed and the quality of the drug is improved. Therefore the purified drug when used in medicine preparation may increase the efficacy and potency of the medicine. The changes found in after purification of Manosilai indicates the necessity of purification. This purification process of Manosilai with Goat’s urine and Boiled Black Gram water can be set as one of the standard purification process of Manosilai. Therefore it can be concluded that after the purification of Manosilai, through the above purification Method, has more efficacy and safety.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg.No: 321416207) |
| Uncontrolled Keywords: | Manosilai ; Red Orpiment ; Standardization ; purification process. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Kambaraman B |
| Date Deposited: | 25 Sep 2018 17:36 |
| Last Modified: | 29 Dec 2018 17:25 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9617 |
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