Kalaiselvi, G G (2017) An open clinical study on Paandu Noi (Iron Deficiency Anaemia) in children with the evaluation of siddha drug Chitramutti Nei. Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
To study the efficacy of Siddha trail drug Chitramutti Nei as internal medicine for the treatment of Paandu Noi in children.This disease mostly resembles Iron deficiency anaemia in modern system. Literature evidences of both Siddha and Modern system were collected and also the ingredients of the trial drug was reviewed as well. For the clinical study, 40 patients were selected based on protocol. This study is conducted after the drug being screened by the Screening committee and approved by the Institutional Ethical Committee (IEC) of Govt siddha medical college Chennai. Selected patients with Paandu Noi diagnosed clinically treated in outpatient department of Govt siddha medical college attached with Arignar Anna Hospital of Indian Medicine, Chennai-106. They were undergone laboratory investigation treated with trial drug, observed for clinical improvement and any adverse reaction. Qualitative analysis of the Chitramutti Nei presence of iron, calcium, starch, chloride and Reducing sugar. Phytochemical analysis of the trial drug shows that presence of Glycosides, carbohydrates, coumarins, phenol. Physico chemical analysis of the trail drug shows the PH 5, Total ash value 2.11%, Moisture: 8.66% shows the safe and effectiveness of the trial drug . In elemental analysis shows that one milliliter of Chitramutti Nei contain 0.512(mg/ml) of iron. Toxicological studies shows that, it has no significant toxic effect. From the preclinical pharmacological study shows that the drug has got a significant haematinic activity and Antihelminthic activity. Bio – statistically analysis of the clinical trial reveals significant p values < 0.05 and < 0.01 and concluded that the treatment is effective and significant. Among the 40 patient‟s good improvement was observed in 24 cases (65%), moderate improvement in 10 cases (25%) and mild improvement in 6 cases (15%). CONCLUSION: Paandu noi is mainly caused by the derangement of Pitham followed by vatham and kabam. The deranged kuttram is settled down by the kaippu suvai in the trial drug there by medicine act effective in cure the disease. In physico chemical Analysis iron was found to be present as effective ingredients in treating anaemia. The Chitramutti Nei reveal no toxicity in the pre clinical studies and hence proven to be safe for human administration. From the pre- clinical pharmacological study it is evident that the trial medicine has significant Haematinic action and Antihelminthic action. Also Chitramutti Nei has been proved clinically. Since as it raises the haemoglobin level in a marked level to the patients given regularly for not less than 30 days along with supplementary diets. Both symptomatic and qualitative improvement were absorbed. For prognosis, routine haematological investigation was taken. During the treatment no adverse events were observed. Statistically it has been proved that it shows significant raise in the haemoglobin level. Hence I concluded that the trial drug Chitramutti Nei will be a better drug that can be used in the treatment of Paandu Noi.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | (Reg.No.321414103) |
| Uncontrolled Keywords: | Paandu Noi ; Iron Deficiency Anaemia ; children ; siddha drug ; Chitramutti Nei ; clinical study. |
| Subjects: | AYUSH > Kuzhanthai Maruthuvam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 24 Sep 2018 02:55 |
| Last Modified: | 02 Jan 2019 01:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9609 |
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