Abinaya, K (2017) Clinical evaluation of Vilva Ennai (a siddha drug) in the treatment of Vali Kanam (Acute Pharyngitis) in children. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
Acute inflammation of the throat is a frequent reason for medical consultations in all age groups. Although generally mild in nature, it may give rise to significant suffering and morbidity, including throat pain, pain on swallowing, high fever, difficulty in eating and drinking, and the need for time off work or school. The literature evidence of both the siddha and modern literatures were reviewed and the reviews and recent studies on the individual drugs of the trial drug were collected. Patients attendingthe OPD of NIS having the compliants of Vali kanam diagnosed clinically and the patients were observed for clinical diagnosis. Classical symptoms of Vali kanam emphasis with the symptoms of pharyngitis like cough, Sore throat, Poor appetite, Lowgrade fever. The Clinical study has been approved by IEC of NIS and the trial was registered in Clinical trial Registry of India. The Authentication of ingredients of the trial drug was done obtained from Medicinal Botanist Dr.D.Aravind MD(S), M.Sc., National Institute of Siddha, Chennai. Purification of drugs and preparation of trial drug was done at Gunapadam Laboratory, Department of Gunapadam, NIS, Chennai. Biochemical Qualitative analysis of trial drug was done in Biochemistry laboratory, Department of Biochemistry, National Institute of Siddha, Chennai. Clinical diagnosis of Vali kanam was done on the basis of the clinical features described in Balavagadam text. The patients with Vali kanam were recruited based on Inclusion and Exclusion criteria and a detailed study was done. Separate proforma was maintained for each patient along with progress chart to monitor the prognosis. The medicine chosen for clinical study of Vali kanam is Vilva Ennai administered internally one time in a day for 5 days. All the patients were adviced to follow healthy dietary regimen during the treatment. The observation on effect of the therapy was encouraging. The trial drug Vilva Ennai have potent anti-inflammatory activity. The physicochemical analysis reveals the high saponification value and Iodine Value, Good refractive index. The trial drug Vilva Ennai, shows the presence of Phytoconstituents such as Alkaloids, Phenols, Steroids, Sugar, Saponin and Protein and the absence of heavy metals and micro- organism, pesticides and aflatoxin. The biochemical analysis revealed the presence of Chloride, Ammonium, Fluoride & Oxalate. The patients have not complained of any adverse effects or difficulties during the course of treatment. Thus the drug is found to be safe and effective in the management of Vali kanam. The clinical efficacy of the drug was analyzed statistically on all the symptoms mentioned in the assessment criteria. The observation made during the clinical study showed that the trail drug vilva ennai was clinically effective. CONCLUSION: The Siddha system of medicines has certainty with safer medications to treat children. In the present study, the trial drug vilva ennai is treated in the children of age group, 8-12 years who are all diagnosed to have Vali kanam. The ingredients of vilva ennai are feasible and useful and these compounds may serve as potentially useful drug at a lower cost since most of them had anti-inflammatory, anti-pyretic activity. Clinical results were found as highly significant before and after treatment. i.e 83% reduction in clinical symptoms after the treatment. The present clinical study has established that vilva ennai is having good result in reducing the majority of the symptoms of vali kanam. This has inturn, provided a further research and opportunity for new drug established in the management of Vali kanam. By encouraging results of above study the drug may be taken for larger study in treatment of Vali kanam.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg.No.321414201) |
| Uncontrolled Keywords: | Vilva Ennai ; siddha drug ; treatment ; Vali Kanam ; Acute Pharyngitis ; children ; Clinical study. |
| Subjects: | AYUSH > Kuzhanthai Maruthuvam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 24 Sep 2018 02:27 |
| Last Modified: | 24 Sep 2018 02:27 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9606 |
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