An open clinical study of siddha drug Karunchoorai Chooranam (Internal) and Kodiveli Thylam (External) in the treatment of Kaalanjaga padai (Psoriasis)

Kopperundevi, S P (2017) An open clinical study of siddha drug Karunchoorai Chooranam (Internal) and Kodiveli Thylam (External) in the treatment of Kaalanjaga padai (Psoriasis). Masters thesis, National Institute of Siddha, Chennai.


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The disease Kaalanjaga padai was taken for the clinical study with Karunchoorai Chooranam as internal medicine and Kodiveli Thylam as external application. For the clinical study, 40 cases were selected based on the approved protocol. The trial was approved by the Institutional Ethical Committee (IEC) (Date of IEC Approval & its Number; 26-08-2015, NIS/IEC/9/2014-15/11). The trial was registered in Clinical Trial Registry of India (CTRI/2017/06/008923) Hence the study is safely executed on patients and there was no adverse drug reactions noted during the study period. Out of the 40 cases, 27 cases were treated in OPD and remaining 13 cases were treated in IPD of Ayothidoss Pandithar Hospital of National Institute of Siddha, Chennai-47. The detailed study on Kaalanjaga padai with reference to its aetiology, pathogenesis, investigations, clinical features, diagnosis and treatment with trial drugs was done. The outcome results of my study was clinically observed by PASI SCORE that is 62.5% of cases had shown good improvement, 20% of cases had shown moderate improvement and remaining 17.5% of cases had shown mild improvement. CONCLUSION: This clinical study validated the Siddha herbal formulation of the trial drug “Karunchoorai Chooranam” is efficacy to human psoriatic population. It was found to be good resulting on Kaalanjaga padi patients in reducing clinical signs and symptoms like itching, scaling and erythema. The literature evidence for this drug is Agasthiyar paripooranam -400which is well-known Shasthric preparation. In this study, no adverse reactions were reported. Hence, it is concluded that the trial drugs are clinically safe. The cost of the trial medicines are low. These drugs are easily available and the dosage is also convenient. The quantitative outcome of PASI score shows there is extremely significant reduction between at the commencement and end of the treatment i.e from 49.52 ±5.52 to15.41 ± 11.52. The qualitative outcome shows there is 62.5% of cases shown good improvement, 20% of cases shown moderate improvement and 17.5 % shown mild improvement. The clinical trial conducted in selected patients was very much satisfactory and the results were encouraging. From above results the trial drug of herbal formulation of “Karunchoorai chooranam” (Internal) and “Kodiveli thylam (External) are well responded in the treatment of Kaalanjaga padai.

Item Type: Thesis (Masters)
Additional Information: (Reg.No: 321413204)
Uncontrolled Keywords: siddha drug ; Karunchoorai Chooranam ; Kodiveli Thylam ; Kaalanjaga padai ; Psoriasis ; open clinical study.
Subjects: AYUSH > Sirappu Maruthuvam
Depositing User: Kambaraman B
Date Deposited: 24 Sep 2018 01:36
Last Modified: 24 Sep 2018 01:36

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