Savitha, S (2017) Safety and Pharmacological profile of Panchakkini Chenduram. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The selection of the drug Panchakkini Chenduram from the literature “Anuboga vaidya navaneetham” part 1, page no 92, Hakkim Abdulla shayabu, for the evaluation of Hepatoprotective, Diuretic and Hematinic activities. The test drug was prepared by the given procedure. All the ingredients were identified and authenticated by the experts. Review of literature in various categories was carried out Siddha aspect and pharmaceutical review disclosed about the drug and the disease. The pharmacological review was done to establish the methodologies. Since the ingredients of Panchakkini Chenduram purified according to the classical methods. The purification process of this drug possible to eliminate their toxins and increases its efficacy and the grinding process of this drug helps to reduce the particle size of the drug for its better bio availability. The drug was subjected to analysis such as physicochemical, chemical and also instrumental analysis which provided the key ingredients present in the drug thus it accounts the efficacy of the drug. Toxicological study was made according to OECD guidelines comprising acute, sub-acute and sub chronic toxicity study. It screens the safety of the drug which attributes its utility in long time administration. Pharmacological study was done. It revealed the Hepatoprotective, Diuretic and Hematinic activities of Panchakkini Chenduram in Wistar albino rat model. Results and discussion given the necessary justification to prove the potency of the drug. Conclusion gives a compiled form of the study and explains the synergistic effect of all the key ingredients and activities that supports the study. Thus the mineral formulation Panchakkini Chenduram is validated for its safety and efficacy for treating Liver disesses, Oliguria and Anaemia it would be a great drug of choice. CONCLUSION: From the literature evidence, Physico Chemical Analysis, Chemical Analysis, Toxicological evaluation and pharmacological studies, the drug Panchakkini Chenduram have Hepatoprotective, Diuretic, Hematinic activity it was concluded that the Panchakkini Chenduram can be issued in the management Liver diseases, Oliguria, and Anaemia.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg No. 321412205) |
| Uncontrolled Keywords: | Panchakkini Chenduram ; Safety ; Pharmacological profile. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 23 Sep 2018 11:52 |
| Last Modified: | 23 Sep 2018 11:52 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9593 |
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