Vinayak, S Nair (2017) Safety and Pharmacological profile of Sanjeevi Theeneer. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The test drug Sanjeevi Theeneer was selected from the Classical literature Siddha Formulary of India for its Hepato protective, Broncho dilator and Anti Histamine studies. Review of literature in various categories was carried out. Siddha aspect, botanical aspect, scientific aspects and Pharmaceutical review disclosed about the drug and the disease. Pharmacological review was done to establish the methodologies. The drug was subjected to analysis such as physicochemical, Preliminary phyto chemical analysis, Gas chromatography analysis and Anti-oxidant Assays. Toxicological study was made according to OECD guidelines comprising the acute, repeated dose 28-days oral toxicity and repeated dose 90-days oral toxicity study. It showed the safety of the drug which proved its utility in long time administration without any harm to the human being. Pharmacological study was done. It revealed the Hepato protective, Broncho dilator and Anti Histamine activities in animal model. This present study suggests Sanjeevi theeneer has remarkable medicinal value in the treatment of Liver diseases. Thus, the herbal formulation Sanjeevi Theeneer is validated for its safety and efficacy for treating liver diseases, Asthma and it would be a great drug of choice and as a Health supplement. CONCLUSION: Sanjeevi Theeneer, the Herbo mineral Classical distillate was prepared as per the Siddha literature. The prepared drug meets all the Traditional quality parameters and also fulfills the Standardization parameters of Theeneer mentioned in AYUSH guidelines. Based on OECD 423,407, 408 the trail drug Sanjeevi Theeneer is considered as nontoxic when studied on Animal Models. The Anti-oxidant Studies, Hepato protective studies, Bronchodilator and Anti Histamine activities was scientifically validated. Hence, it can be concluded as a safe and therapeutically effective drug in Liver diseases and Bronchial Asthma and moreover can be used a rejuvinative Health supplement.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg No. 321412207) |
| Uncontrolled Keywords: | Sanjeevi Theeneer ; Safety ; Pharmacological profile. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 23 Sep 2018 11:44 |
| Last Modified: | 23 Sep 2018 11:45 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9592 |
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