Mullaikarasi, U (2017) A clinical study on Samuthra Pazha Nei in the treatment of Neer Peenisam (Maxillary Sinusitis). Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The aim of the study is to evaluate the therapeutic efficacy of Samuthra Pazha Nei in Neer Peenisam. The Protocol of this study had been submitted to Institutional Ethics Committee of National Institute of siddha. On 26-08-2015 and then approval was got from IEC for conducting this clinical study. The IEC no is NIS/iec/9/2014-15/4-26.08.2015. This clinical study was registered in Clinical Trial Registry of India on 7-3-17. And the CTRI NO is CTRI/2017/03/008053. The herbal raw drugs were purchased from raw drugs store of Paris corner and authenticated by Botanist Dr.D.Aravind, MD(S), M.Sc.(Medicinal Plants)., National Institute Siddha and Metals were authenticated by Siddha Central Research Institute, Arumbakkam and the medicine was prepared in the Gunapadam laboratory of National Institute of Siddha. Most of the ingredients of the drug Samuthra Pazha Nei possess anti Inflammatory, Analgesic and anti-oxidant activity. Biochemical Analysis (Qualitative Analysis) was done in the Biochemistry lab of National Institute of Siddha and Qualitative Analysis & Quantitative analysis was done in Sathyabama University. For the clinical study, 70 cases were screened and 40 cases were selected based on the Inclusion and Exclusion criteria. All the cases were treated in OPD of Ayothidoss Pandithar Hospital of NIS, Chennai. The clinical Trial was conducted in 40 patients of Neer Peenisam with the trial drug Samuthra Pazha Nei at the dose of 4ml twice a day with adjuvant of hot water for 48 days. Blood Investigation was carried out before and after treatment and data were recorded in the case report forms. Radiological Investigations (X-ray for Para nasal sinuses) were also done before and after treatment. Clinical assessment Progress was done once in 8 days for OPD patients. The Pharmacological study reveals that the trial drug has Anti-inflammatory activity. Physico-chemical analysis, Phyto chemical analysis, Gas Chromatography with Mass Spectrometry, Thin Layer Chromatography, High Performance Thin Layer Chromatography has also be done for trial drug. Biochemical parameters: Absolute eosinophil count: Out of 40 patients, 17.5% of patients had elevated absolute eosinophil count in before treatment. After treatment AEC levels of 12.5% of patients become normal and 5% of patients were moderately reduced. Erythrocyte sedimentation rate: Out of 40 patients, after treatment ESR of 15% of patients become normal, 20 % of patients moderately reduced and 15% of patients were increased. X-ray Para nasal sinuses: X-rays of PNS shows moderate clearance of sinuses in 25% (10 patients). Clinical symptoms: Clinical symptoms showed 30% of patients good improvement, 50% of patients moderate improvement, 12.5% of patients mild improvement and 7.5% of patients poor improvement.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg.No: 321411204) |
| Uncontrolled Keywords: | Samuthra Pazha Nei ; Neer Peenisam ; Maxillary Sinusitis ; Clinical study. |
| Subjects: | AYUSH > Maruthuvam |
| Depositing User: | Kambaraman B |
| Date Deposited: | 23 Sep 2018 08:27 |
| Last Modified: | 23 Sep 2018 11:02 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9585 |
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