Comparison study of topical retinoids adapalene Vs tazarotene in the treatment of Acne Vulgaris.

Amudha, R (2009) Comparison study of topical retinoids adapalene Vs tazarotene in the treatment of Acne Vulgaris. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Acne Vulgaris is an extremely common disease with increased prevalence among adolescents. Although acne is not a life-threatening condition, it can cause substantial morbidity. Acne and resulting scarring can have a psychological impact including lowered self image and selfesteem, social impairment and anger. Even those with minimal acne experience psychological effects and for those people, the psychosocial burden may be the most significant problem with this disease. It has been shown that even clinically mild to moderate acne can be associated with higher rates of depression and suicidal thoughts among adolescents than other chronic and disfiguring skin diseases. In summary, acne is an important condition and appropriate intervention is essential to prevent complications such as acne scarring, psychological impacts and secondary impaired social function. In the last 25 years, numerous topical and systemic drugs have been developed for the treatment of acne vulgaris. The primary lesions of acne are the microcomedones, which are not visible to the naked eye but require special attention with regard to the development of therapeutic strategies. They represent the central precursor lesions that evolve into either non inflammatory comedones or inflammatory macules, papules and pustules. Retinoids are derived from Vitamin A. They were first observed to be extremely effective in curing acne since 1962. Retinoids influence the proliferation and differentiation of cells and therefore reverse the abnormal desquamation by affecting the follicular epithelial turnover. This leads to an expulsion of mature comedones and suppression of microcomedone formation. The change of the microclimate in the pilosebaceous follicle by prevention of hypercornification promotes an inhospitable aerobic environment for P.acnes and is likely to enhance the penetration of other topical drugs. Various in Vitro and in Vivo studies also demonstrated direct antinflammatory activity of topical retinoids. Furthremore, retinoids modulate the expression of the transcription factors, such as AP-1, that regulate genetic expression of growth factors and degradative enzymes involved in inflammatory responses Retinoids are also involved in the induction of apoptosis by a variety of mechanisms either associated with or independent of binding of retinoid receptors. AIM OF THE STUDY : The aim of the study is to compare the efficacy of topical adapalene and topical tazarotene in the treatment of acne vulgaris with each other. The agents compared were the following:- 1) 0.1% Adapalene cream, 2) 0.1% Tazarotene Cream. CONCLUSION : * In this study, Acne Vulgaris showed increased prevalence among males. * The increased prevalence was noted in the age group of 15-20 years irrespective of the sex. * In this study, pronounced incidence of acne vulgaris was noted among students. * The precipitating factors noted in this study were more among male patients. * Patients treated with 0.1% adapalene cream showed better response compared to patients treated with 0.1% tazarotone cream. * Among those improved with topical adapalene cream and topical tazarotene cream good response was observed in the age group of 15-20 years. * Nearly 75% of the lesions resolved after 10 weeks of treatment with topical adapalene, where as only 30% of the lesions resolved with topical tazarotene. * The side effects of topical adapalene cream were very minimal and transient the side effects with topical tazarotene were severe and prolonged.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Topical retinoids adapalene ; Tazarotene ; Acne vulgaris ; Comparison study.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Jul 2017 03:25
Last Modified: 05 Jul 2017 08:39

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