A Study of 300 cases of Allergic Contact Dermatitis.

Thilak, S (2008) A Study of 300 cases of Allergic Contact Dermatitis. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Allergic Contact Dermatitis is a very common type of skin disorder seen among patients attending dermatology clinics. Allergic contact dermatitis occurs when the skin comes in contact with an allergen that the skin is sensitive or allergic to. Allergic contact dermatitis occurs more commonly in adults. In other words Allergic contact dermatitis is caused by the body's reaction to something that directly contacts the skin. Many different substances can cause allergic contact dermatitis, which are called 'allergens'. like fragrances, small molecule preservatives, etc. Usually these substances cause no trouble for most people, and may not even be noticed the first time the person is exposed. But once the skin becomes sensitive or allergic to the substance, any exposure will produce a rash. Allergic contact dermatitis is the inflammation of the skin manifested by varying degrees of erythema, edema, and vesiculation. It is a delayed type of induced sensitivity (allergy) resulting from cutaneous contact with a specific allergen to which the patient has developed a specific sensitivity. Diagnosis of Allergic contact dermatitis is done by doing Patch tests. AIMS OF STUDY : 1. To study the incidence of various allergens in 300 patch test positive cases for that allergens. 2. To study the age incidence among patients of contact dermatitis to various allergens. 3. To study the sex incidence among patients of contact dermatitis to various allergens. 4. To study the association of Allergic contact dermatitis and Atopy. 5. To study the association between the duration of exposure of an antigen required for clinical manifestation of allergic contact dermatitis. 6. To find the incidence of occupational and non occupational causes of allergic contact dermatitis. 7. To study the association between Diabetes mellitus and allergic contact dermatitis. 8. To study the relationship between CD4 cell counts and allergic contact dermatitis. CONCLUSION : 1. Allergic contact dermatitis to cement was found to be the commonest cause of ACD in the study. Potassium dichromate was found to be the most frequent allergen to be positive in the Indian standard series. 2. Most cases of allergic contact dermatitis fall in the 41 to 50 years age category. 3. Male to female ratio of the total cases was 2.48:1. 4. There was an increased incidence of ACD in atopic patients and more incidence of 2+ positivity. Nickel was the most common allergen causing ACD in atopic individuals. Eosinophilia was more common among atopics and in patients with ACD to Nickel. 5. The average duration between the exposure of the allergen and manifestation of ACD was commonly between 2 to 5 years. 6. Occupational cases of allergic contact dermatitis were twice common than non-occupational cases. 7. Patients with Diabetes mellitus have increased incidence of 1+ positivity due to immuno suppression. 8. The most common presentation of allergic contact dermatitis in the study was that of hand eczema. 9. CD4 cell counts in the 3+ group were found to be more than 2+ and 1+ groups.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Allergic Contact Dermatitis ; Case study.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Jul 2017 03:19
Last Modified: 05 Jul 2017 08:38
URI: http://repository-tnmgrmu.ac.in/id/eprint/957

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