Cutaneous Hypopigmentation: A Study of 300 cases.

Ankit, Agarwal (2008) Cutaneous Hypopigmentation: A Study of 300 cases. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Skin is the largest organ of the body and the only organ which is visible and is in direct contact with the environment It has been said that the greatest problems in this world are very tiny, the atom, the ovum and a touch of pigment. The largest organ of the body very commonly suffers from this touch of pigment. Numerous skin conditions cause alteration in the normal pigmentation resulting in significant psychological morbidity due to cosmetic disfigurement. Pigmentary disturbances may be congenital or acquired, circumscribed or generalised, hypomelanotic or hypermelanotic. This study strives to study the various skin conditions presenting as hypopigmentation. With attention to variability of extent of hypomelanosis, history of evolution, attention to hue and awareness of ancillary features, the differential diagnosis will be narrowed down and definite diagnosis will be arrived at with the help of relevant investigations. An attempt will also be made to find the relative incidence of each condition. AIM : 1. To study the relative incidence of the various disorders causing a hypopigmented lesion in a random sample of 300 cases from the OPD cases at the Department of Dermatology, Madras Medical College, Chennai 2. To study the site, distribution and characteristics of the hypopigmented lesion in each of the diseases 3. To study the age and sex distribution of the commonest diseases presenting with a hypopigmented lesion 4. To make an attempt to classify the various conditions on basis of whether the hypopigmented lesion is scaly or non scaly 5. To look for the other conditions or systemic abnormalities associated with the diseases 6. To correlate the clinical findings with histopathology in selected cases. Conclusion : 1. Tinea versicolor was the condition presenting most commonly with a hypopigmented lesion. Upper trunk was found to be the commonest site. 2. The other common diseases in descending order of frequency were postinflammatory hypopigmentation, early vitiligo and Hansen’s disease. 3. Polymorphous light eruption was the most common cause of postinflammatory hypopigmentation followed by psoriasis, pityriasis rosea and parapsoriasis 4. Polymorphous light eruption was seen more commonly in females with dorsa of forearms and nape of neck being the commonest sites. 5. Male predominance was noted in almost all groups of diseases except polymorphous light eruption and early vitiligo. 6. 20-30 was the commonest age of presentation in almost all groups 7. Nevus achromicus formed the commonest cause among nevoid disorders. 8. Classification on basis of surface of hypopigmented lesions (scaly/non scaly). Scaly lesions Tinea versicolor Resolving pityriasis rosea Pityriasis lichenoides chronica Resolving psoriasis Polymorphous light eruption Lichen striatus Epidermodysplasia verruciformis Non scaly lesions Hansen’s disease Early Vitiligo Hypomelanosis of Ito Nevus achromicus Idiopathic guttate hypomelanosis Tuberous sclerosis 9. Certain associations like seborrheic dermatitis, acne and dermatophytosis with tinea versicolor and diabetes with vitiligo were noted. 10. Histopathology was helpful in diagnosis of cases like psoriasis, parapsoriasis and Hansen’s disease while it was not contributory in cases of pityriasis rosea.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Cutaneous ; Hypopigmentation ; case Study.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Jul 2017 02:15
Last Modified: 05 Jul 2017 08:29

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