Therapeutic Efficacy of Photochemotherapy in various Dermatoses.

Subashini, Karthikeyan (2007) Therapeutic Efficacy of Photochemotherapy in various Dermatoses. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Photochemotherapy is one of the oldest known light dependant therapies in medicine. Psoralen photochemotherapy is a combination of psoralen and long wave ultraviolet radiation that brings therapeutically beneficial results not produced by either drug or irradiation alone. Initially plant sources of psoralen were used and patients were exposed to sunlight for a specified period. This method has been modified over several years and synthetic drug preparations and also artificial sources of light have been introduced. This has made possible the accurate measurement of the UV dose given and also helped in better treatment results. Initially photochemotherapy was used in the treatment of vitiligo. Gradually its uses have expanded and is currently being used in the treatment of several common and uncommon skin diseases. But PUVA has also got various side effects which are both acute and long-term effects. Higher cumulative dosage is known to cause various skin cancers. Hence appropriate administration and regular monitoring is very essential. Also PUVA therapy requires good patient compliance and regular treatment schedules. Thus if the correct category of patients are selected and PUVA administered as per various guidelines mentioned it can indeed be an extremely beneficial therapy for various diseases. The study here includes the efficacy of PUVA in various common skin conditions encountered in the Dermatology department. AIM OF THIS STUDY : Photochemotherapy is an efficient method of treating various dermatological disorders. With appropriate administration and regular monitoring it can be used safely in the treatment of various common dermatoses. OBJECTIVES: 1. To evaluate the efficacy of PUVA therapy in the treatment of a. Psoriasis vulgaris involving >20% of Body surface area, b. Vitiligo vulgaris involving >20% of Body surface area, c. Generalized lichen planus and d. Parapsoriasis. 2. To asses the side effects of PUVA during treatment. 3. To observe the patient compliance for PUVA therapy. CONCLUSION : 1. PUVA is an effective and safe therapy for the treatment of Psoriasis vulgaris as evidenced by the response rate of 90% seen in our study with only minimal side effects like erythema, nausea and pruritus. 2. PUVA also induces a moderate amount of repigmentation in Vitiligo vulgaris during 6 months of therapy. Hence careful patient counselling is needed before starting PUVA, as it takes a long duration to induce extensive repigmentation. 3. PUVA also results in satisfactory improvement in generalized Lichen planus and helps in the clearance of Parapsoriasis. 4. Thus PUVA can be considered a valuable mode of therapy for the above conditions like Psoriasis vulgaris, generalized Lichen planus and Parapsoriasis. It is also useful in Vitiligo when patient does not respond to other modalities of treatment.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Therapeutic Efficacy ; Photochemotherapy ; Dermatoses.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Jul 2017 02:03
Last Modified: 05 Jul 2017 08:27

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