A study on chronic autoimmune urticaria and efficacy of autologous serum therapy.

Sindhuja, R (2007) A study on chronic autoimmune urticaria and efficacy of autologous serum therapy. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION ; Chemical peeling is a technique used to improve the appearance of the skin. A chemical solution is applied to the skin, which causes it to separate, peel off, and allows new skin to regenerate. The new skin is smoother and less wrinkled than the old skin, and may also be more even in color Dermatologists have used various peeling agents for decades and are experts in performing all types of this chemical surgery. This concept dates back to Roman times. Superficial and medium depth skin peeling with trichloroacetic acid has been a well documented therapy in United states since atleast 1960. Dr. Baker and Gordon pioneered chemical peeling with phenol in the year 1961. Chemical peeling one of the latest treatments available for the about disease in modern era. Superficial and medium depth skin peels can create dramatic improvement in the skin but the results were not long lasting as those with phenol peels. The use of retinoic acid alpha hydroxyl acids, broad-spectrum sunscreens and skin bleaches as part of a post-peel maintenance programme has allowed patients maintain the improvement in skin for far longer. Microdermarasion is a non- chemical, non- invasive modality for treating superficial skin blemishes resulting from trauma, aging, prolonged exposure to skin or mild acne. Microdermabrasion has been used successfully since atleast 1992 to treat acne, fine lines and wrinkles, unwanted pigmentation and other superficial skin damage. Even though various modalities of treatment are available for acne, it still pores a therapeutic problem to the attending dermatologist. The advent of new and potent topical therapeutic agents, chemical peeling and dermabrasion has resulted in significant improvement for us to treat many forms of acne. This study attempts to find the therapeutic response to various chemical peels like salicylic and glycolic acid on acne along with microdermabrasion. AIM OF THE STUDY ; The aim of the study is to compare the efficacy of glycolic acid and salicylic acid peels in the treatment of acne vulgaris with each other and as combination with microdermabrasion. The agents compared were the following: Glycolic acid alone, Glycolic acid and microdermabrasion, Salicylic acid alone, Salicylic acid and microdermabrasion. CONCLUSION : 1. Patients in whom chemical peeling was followed with microdermabrasion showed better results compared to patients in whom chemical peeling alone was done. 2. If chemical peeling is done alone or combined with microdermabrasion, salicylic acid peel is superior to glycolic acid peel in the treatment of acne. 3. Though salicylic acid peel with microdermabrasion showed better results, the improvement rate was more with glycolic acid with microdermabrasion than salicylic acid peel with microdermabrasion. 4. Hyper-pigmentation is more common side effect with salicylic acid peel, while erosion and burning sensation were more with glycolic acid peel. 5. Though the side effects observed with these peels reduced by itself, application of emollients, mild steroids and sun screeners hastened the recovery.

Item Type: Thesis (Masters)
Uncontrolled Keywords: chronic autoimmune urticaria ; autologous serum therapy.
Subjects: MEDICAL > Dermatology Venereology and Leprosy
Depositing User: Subramani R
Date Deposited: 05 Jul 2017 01:56
Last Modified: 05 Jul 2017 08:26
URI: http://repository-tnmgrmu.ac.in/id/eprint/944

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