Thomas, Babu (2018) Association between lipid profile and liver function test in type 2 diabetics. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
INTRODUCTION: Diabetes mellitus (DM) is currently defined as “a group of common metabolic disorders that share the phenotype of hyperglycemia”. The prevalence of both type 1 and type 2 DM is increasing worldwide, the prevalence of type 2 DM rising more rapidly. This is attributed to increasing obesity, reduced activity levels, and the aging of the population. DM is expected to be a leading cause of morbidity in the future due to its increasing incidence. Multiple organ systems are affected due to the metabolic dysregulation associated with DM .Lipolysis and free fatty acid flux from adipocytes are increased, leading to increased lipid synthesis in hepatocytes due to insulin resistance in adipocytes. This accounts for the dyslipidemia found in type 2 DM. There is an association between diabetes and liver injury. Accumulation of glycogen in liver leads to hepatomegaly and liver enzyme abnormalities in poorly controlled diabetes patients. Nonalcoholic fatty liver disease (NAFLD) is frequently encountered in type 2 diabetic patients.NAFLD represents a spectrum of histological findings from hepatic steatosis or fat accumulation in hepatocytes to hepatic steatosis with a necroinflammatory component that may or may not have fibrosis, or NASH. The lipid profile, liver function and histopathological changes in type 2 diabetic individuals are areas of active research.This study is aimed at studying the association of lipid profile and liver function in type 2 diabetic individuals –through FLP, LFT and USG for fatty liver, in individuals attending an Institute of Non-Communicable diseases at a tertiary care teaching hospital in Tamil Nadu, India. Information from this study could be of utility for protocol formation in the management and prevention of diabetes and its complications. OBJECTIVE: To study the association between lipid profile and liver function test in type 2 diabetics. METHODS: The study population consisted of 100 type 2 diabetic patients attending Diabetics clinic, Institute of non communicable diseases, Government Royapettah hospital, Government Kilpauk medical college, Chenna.FBS, PPBS, LFT, FLP and USG abdomen for detecting fatty liver were done for all paticipants.ALT /AST > 30 and TC>200 ,TGL>150 were taken as elevated and their association with fatty liver was studied. Alcoholics with fatty liver were not included. RESULTS: The 100 participants in the study included 49 females and 51 males.Mean age was 52.6 +/- 10.426.).7 out of the 100 were alcoholics. 73 of the total had raised ALT/AST.47 participants had raised TC and TGL.Both LFT and FLP were raised in 46 individuals. Out of the 71 participants with elevated LFT (alcoholics excluded) 62 had fatty liver. 43 of the 44 participants with elevated FLP had fatty liver..43 participants had all the 3 findings-elevated FLP,LFT and fatty liver in USG.Statistical analysis showed there is significant association between FLP and LFT and FLP,LFT and fatty liver(p <0.01). CONCLUSION: 1 Type 2 diabetic patients are prone to elevations in lipid profile. 2. Individuals with Type 2 diabetes have a higher incidence of LFT abnormalities than non diabetic individuals. 3. There is higher incidence of fatty liver in type 2 diabetics. 4. Derangement of FLP and LFT has statistically significant correlation with fatty liver. The prevalence of both type 1 and type 2 DM is increasing worldwide, the prevalence of type 2 DM is rising more rapidly. Dyslipidemia,liver enzyme abnormalities and Nonalcoholic fatty liver disease (NAFLD) is frequently encountered in type 2 diabetic patients. With good glycemic control and regular monitoring of FLP, LFT and fatty liver, there is scope for prevention from progression of fatty liver into cirrhosis and chronic liver disease. Hence routine monitoring of LFT and USG for faty liver along with flp in patients with type 2 diabetes should occur at the start of drug therapy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Diabetes ; Fasting lipid profile ; Liver function test ; Non alcoholic fatty liver disease ; Ultrasonography. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 08 Sep 2018 14:44 |
| Last Modified: | 11 Sep 2018 02:24 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9435 |
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