Ani Thampi, - (2018) Prospective study on clinical outcomes of sputum positive tuberculosis in newly detected diabetes patients in comparison to non diabetic patients. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.
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Abstract
BACKGROUND: The link between tuberculosis (TB) and diabetes mellitus (DM) has occupied the centre stage of discussion. Experts have raised concern about the merging epidemics of tuberculosis and diabetes particularly in the low to medium income countries like India and China that have the highest burden of TB in the world, and are experiencing the fastest increase in the prevalence of DM. The huge prevalence of DM in India, may be contributing to the increasing prevalence of TB. We discuss the epidemiology, clinical features, microbiology and radiology, and management and treatment outcomes of patients with tuberculosis and diabetes mellitus. METHOD: Data were collected from 100 patients with sputum positive tuberculosis and were screened for presence of diabetes. Detailed history, chestX-rayand sputum analysis were done and patients were followed up until treatment RESULTS: There was male preponderance and the mean age group among diabetics patients were 51.5 ± 9 years compared to 34.2 ±7 .26 years. Diabetic patients had more of chest pain, hemoptysis and dyspnoea compared to non-diabetics. Diabetic patients had more sputum positivity rates compared to non-diabetics.38 % of the diabetic patients had cavities in chest x-ray compared to 20 % amount non diabetics.48 % of the diabetic patients had lower zone infiltrates compared to 20 % in non-diabetics. Sputum conversion rates were84% in non-diabetic TB patients when compared to 70% in diabetic TB patients. Failure rates were high as 4% in diabetic patients but not statistically significant CONCLUSION: All patients with pulmonary tuberculosis should be screened for diabetes mellitus and should be effectively treated for the same. Pulmonary Tuberculosis patients who have diabetes tend to have higher sputum positivity rates and delayed sputum conversion if glycemic levels are poorly controlled. Chest radiographs of such patients show multiple cavitations with predominant lower lobe involvement. The rates of treatment failures and treatment outcomes are adversely affected by the presence of diabetes.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | clinical outcomes ; sputum positive tuberculosis ; newly detected diabetes patients ; comparison ; non diabetic patients ; Prospective study. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 08 Sep 2018 13:17 |
| Last Modified: | 11 Sep 2018 01:48 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9427 |
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