Study of lipid peroxidation using malondialdehyde and lipid profile in diabetes mellitus to assess the severity of diabetes mellitus

Suresh Kumar, M (2018) Study of lipid peroxidation using malondialdehyde and lipid profile in diabetes mellitus to assess the severity of diabetes mellitus. Masters thesis, Thanjavur Medical College, Thanjavur.


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BACKGROUND: Diabetes is usually accompanied by increased production of free radicals or reactive oxygen species which produces oxidative stress. Degree of lipid peroxidation was measured in terms of MDA. The decomposition of lipid peroxides forms many cytotoxic compounds like malondialdehyde (MDA).So oxidative stress can be measured by monitoring the changes in malondialdehyde. Lipid peroxidation and lipid profile are elevated in Diabetes. OBJECTIVE: To study the level of lipid peroxide using malondialdehyde and lipid profile in IDDM and NIDDM. To find out the correlation between Lipid peroxide and Lipid profile in both types of diabetes mellitus.To find out the correlation between lipid peroxide and lipid profile with glycaemic control (HbA1C).To assess the severity of Diabetes Mellitus. METHODS: 150 patients were selected for this prospective study over a period of 6 months. Out of which 50 persons belong to healthy control group , 50 patients belong to NIDDM and 50 to IDDM group. Levels of serum Malondialdehyde , lipid profile, Blood sugar status, Renal function test ,urine routine were measured during their outpatient visit. RESULTS: Significant difference between levels of serum malondialdehyde in controls and diabetics with mean 3.25 and 5.31 μmol/L respectively and its increase is statistically significant (P = 0.0001). significant increase in MDA levels of NIDDM group (Mean 5.68 micromol/L) as compared to IDDM group (Mean 4.95 micromol/L). CONCLUSION: Oxidative stress is observed more in diabetes mellitus patients. Lipid peroxidation is the marker for oxidative stress and it is statistically significant in our study. Compared to NIDDM , IDDM patients with good glycemic control have low level of serum malondialdehyde .Lipid profile is increased in poor glycemic controlled patients (both IDDM and NIDDM patients) and it is reflected in high serum malondialdehyde levels. It is found to be statistically significant in our study group. Strict glycemic control is needed for reducing oxidative stress in diabetes mellitus patients and to prevent its complications.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Lipid peroxide ; Malondialdehyde ; Hyperglycemia ; oxidative stress ; Free radicals.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 27 Aug 2018 17:00
Last Modified: 27 Aug 2018 17:00

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