Samuel Jeyaraj, Daniel (2006) A Clinico Pathological Study of 300 cases of warts in immunocompetent and immunocompromised patients. Masters thesis, Madras Medical College, Chennai.
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Abstract
Among all the common cutaneous viral infections, warts are the commonest. Warts form an interesting study because of their frequent occurrence, varied morphological appearance, relatively asymptomatic behavior and their unpredictable course. Warts are mostly self-limiting and benign conditions. But the possibility of malignant in some types like genital warts, epidermodysplasia verruciformis and the heterogeneity in serotypes have additional importance in their study. The possibility of increase in both oral and anogenital pathologic conditions due to HPV in patients infected with HIV is of concern and is the focus of numerous current research studies. HIV-infected women are at a higher risk for cervical HPV infection with high oncogenic types of HPV leading to cervical intraepithelial neoplasms. HIV-infected men are at increased risk for anal HPV infection with high oncogenic types of HPV with persisting type of infection. Recent studies have shown an increased risk of oral warts in HIV-infected individuals despite treatment with highly active antiretroviral therapy (HAART). It appears that transplant recipients are susceptible to infections with diverse HPV types including rare types, that multiple infections are possible and that the site specificity of certain HPV types differs from normal population and is often recalcitrant, painful and deeply affects the patient’s quality of life. AIMS AND OBJECTIVES OF THE STUDY : 1. To study the prevalence of various types of warts among the patients attending the Dermatology department. 2. To study the age and sex distribution of various types of warts 3. To find out the clinical presentations of different morphological types and blood group distribution in the study group 4. To find the clinical presentation and distribution of different morphological types in Human Immunodeficiency virus infected, Renal transplant recipients. 5. The histopathological aspects of various types of warts encountered. CONCLUSION : 1. The commonest age group affected by warts was the 16 – 25 year age group; males were commonly affected than females. 2. Verruca vulgaris was the most common type of wart found in this study, followed by plantar warts, anogenital warts and plane warts. 3. The most common sites affected by verruca vulgaris were fingers, hands, forearms, dorsum of feet, indicating trauma as the most common mode of spread. 4. Immunocompromised patients, whether due to disease or drugs showed a profusion. 5. Histopathological features of various clinical types of warts were characteristic and classical as described. 6. A predominance of blood group B was observed in the present study, which needs further evaluation in a larger group. 7. In HIV positive patients increase in anogenital warts with florid manifestations was seen especially in homosexual men. 8. In Renal Transplant recipients the decreased incidence of warts in this study may be due to the difference in skin type, immunosuppressant used, ethnic group and geographical location which needs further evaluation in a larger population.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | immunocompetent ; immunocompromised patients ; Clinico Pathological Study. |
| Subjects: | MEDICAL > Dermatology Venereology and Leprosy |
| Depositing User: | Subramani R |
| Date Deposited: | 05 Jul 2017 01:08 |
| Last Modified: | 05 Jul 2017 08:19 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/935 |
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