A study of CK 19 expression in papillary lesions of thyroid

Geetha, T (2018) A study of CK 19 expression in papillary lesions of thyroid. Masters thesis, Tirunelveli Medical College, Tirunelveli.

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Abstract

INTRODUCTION: Papillary carcinoma is the most common thyroid malignancies. Sometimes papillary areas associated benign lesions may mimic papillary carcinoma thyroid such as multinodular goiter, graves disease etc. CK 19 is a simple intermediate filaments, helps in structural integrity of epithelial cells. Expression of CK 19 helps to distinguish between benign and malignant papillary lesions. AIMS AND OBJECTIVES: To study the usefulness of CK 19 to differentiate papillary carcinoma thyroid from benign lesions showing papillary areas. MATERIALS AND METHODS: 46 Cases were from collected from department of pathology, tirunelveli medical college during a period of 2015 -2017. Out of 46 cases 29 cases were papillary carcinoma thyroid, 17 cases were papillary hyperplasia. RESULTS: Out of 29 cases of papillary carcinoma, 28 cases show diffuse positivity, 1 case shows negative expression. Out of 17 cases of papillary hyperplasia, 12 cases of papillary hyperplasia in multinodular goiter, 4 cases of hashimotos thyroiditis with papillary areas, 1 case with graves disease. 14 cases show negative stain, 2 cases show focal positivity, 1 case shows diffuse positivity. CONCLUSION: Papillary carcinoma shows strong, diffuse cytoplasmic and membranous positivity. Papillary hyperplasia negative stain, some cases show focal positivity. CK 19 shows a 93 % sensitivity and specificity. CK 19 is a useful marker to differentiate papillary carcinoma from papiilary hyperplasia.

Item Type: Thesis (Masters)
Additional Information: Reg.No.: 201513303
Uncontrolled Keywords: Papillary carcinoma ; multinodular goiter ; graves disease ; hashimotos thyroiditis ; CK 19 (cytokeratin 19).
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 19 Aug 2018 04:56
Last Modified: 19 Aug 2018 04:56
URI: http://repository-tnmgrmu.ac.in/id/eprint/9315

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