Expression of HLA 1 and CD 8 in cancer cervix patients

Padmavathi, R (2018) Expression of HLA 1 and CD 8 in cancer cervix patients. Masters thesis, Coimbatore Medical College, Coimbatore.


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BACKGROUND: The local tissue immune status may play a role in cancer cervix. The aim of our study is to examine the expression of HLA 1 and CD 8 in various types of carcinoma cervix and to correlate them according to their grades of malignancy. METHODS: We chose the hysterectomy and small cervical biopsy tissues of cervical cancer and then detected the expression of HLA 1 and CD 8 using SP immunohistochemistry. The associations of the HLA 1 and CD 8 expression with the clinicopathologic profiles of the patients were analyzed. RESULTS: The positive staining of HLA class 1 antigen in well differentiated carcinoma is 7 out of 24 SCC cases and the negative staining of HLA class 1 in poorly differentiated form of SCC is 5 out of 24 cases. This also correlates with the expression of CD 8. CONCLUSION: The expression of HLA 1 and also CD 8 are downregulated in poorly differentiated carcinomas and it is more efficiently expressed in well differentiated forms which indicates that there is a good prognosis in well differentiated carcinomas because of HLA 1expression and cytotoxic destruction of tumor cells by CD 8 + lymphocytes.

Item Type: Thesis (Masters)
Uncontrolled Keywords: HLA Class 1 antigen ; CD8 ; Cervical cancer ; Immune surveillance ; Immune escape.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 19 Aug 2018 03:39
Last Modified: 19 Aug 2018 03:39

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