Bcl2 expression in breast carcinoma and its association with other clinicopathologic factors

Sharmila, G (2018) Bcl2 expression in breast carcinoma and its association with other clinicopathologic factors. Masters thesis, Coimbatore Medical College, Coimbatore.


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BACKGROUND: Anti Apoptotic marker(Bcl2) can be a new advance front in the assessment of prognosis of breast cancer. Apoptotic and Antiapoptotic proteins along with other proteins involved in cell proliferation and control plays a complex role in the etiopathogenesis of breast cancer. AIM OF THE STUDY: Our aim is to study the Bcl2 expression in breast carcinoma and its association with other clinicopathologic factors such as tumour size,lymphnode status, ER/PR, Her2 expression, histologic grade and Nottingham prognostic index MATERIALS AND METHODS: 30 cases of breast carcinoma including IDC-NOS type and some special histologic subtypes are randomly selected and representative sections are taken. Immunohistochemistry for Bcl2, ER, PR, Her2/neu was done. Bcl2 expression in those cases are observed, statistically analysed and compared with other clinicopathologic factors such as tumour size, lymphnode status, ER/PR, Her2/neu expression and Nottingham prognostic index. RESULTS: 7 out of 30 cases( 23.3 %) shows positivity for Bcl2,all of them show strong cytoplasmic positivity. Bcl2 positive cases(7/7) were positive for both ER and PR(p value <0.004 significant). But none of the Bcl2 positive cases shows immunoexpression for Her2/neu. Bcl2 positive cases shows statistically significant correlation with lower histologic grade (p value < 0.006 ) in ductal carcinoma NS type and all mucinous carcinoma(p value <0.025), small tumour size(p value<0.024) in ductal carcinoma NS type. It doesn’t correlation with lymphnode. CONCLUSION: To conclude that, Bcl2 expression in invasive ductal carcinoma is directly correlated with lower histologic grade(well differentiated tumours), small tumour size, ER+, PR+ Status of individual, all cases of mucinous carcinoma of breast. It inversely correlated with Her2/neu status,other special histologic subtypes(metaplastic and secretory carcinoma). These data promises on a new approach to enhance the efficacy of endocrine treatment in estrogen receptor-positive (ER+) breast cancer by negating the antiapoptotic effect of BCL-2 by using BH3 mimetics.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Anti Apoptotic marker(Bcl2) ; breast carcinoma ; clinicopathologic factors.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 19 Aug 2018 03:29
Last Modified: 19 Aug 2018 03:29
URI: http://repository-tnmgrmu.ac.in/id/eprint/9306

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