Histomorphology of papulosquamous skin lesions with special stain application: An analysis

Uma, V (2018) Histomorphology of papulosquamous skin lesions with special stain application: An analysis. Masters thesis, Coimbatore Medical College, Coimbatore.


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BACKGROUND: Papulosquamous skin lesions are the largest group of skin disorder seen by dermatologists and pathologists. Psoriasis and lichen planus are the most common skin lesions among papulosquamous skin lesions. The prevalence of psoriasis ranges from 0.09% to11.4%. The incidence of psoriasis is 100 per 1 lakh population. In India prevalence of psoriasis is 0.44-2.8%.The prevalence of lichen planus is 0.22-5% worldwide. In India the prevalence of lichen planus is 0.9 -1.8. In papulosquamous patients, clinical diagnosis is possible mostly. However in cases with atypical presentation, histopathology is needed for further categorization. Although histopathology is the gold standard for most skin lesions, certain skin lesions require some special stains to confirm the diagnosis. Periodic Acid Schiff is useful in staining basement membrane and colloid bodies in lichen planus. In present study, PAS stain is applied to distinguish lichenoid reaction patterns and lichen planus and its statistical significance is analyze. AIM OF THE STUDY: To study the clinical features and histomorphology of papulosquamous skin lesions with special stain application over a period of one year at Coimbatore Medical College Hospital MATERIALS AND METHODS: A total of 129 cases of papulosquamous skin lesions over 1 year were taken for study. Diagnosis was confirmed by histopathological examination. Periodic Acid Schiff stain was performed in clinically diagnosed lichen planus cases. RESULTS: Among 129 cases, 86 (67%) cases show positive histopathological correlation. 80% positive correlation seen with psoriasis. In 86 cases 45% of the cases were psoriasis followed by lichen planus. Males are most commonly affected. Extremities are the most common sites of involvement. PAS stain increase the diagnostic accuracy of lichen planus. CONCLUSION: Clinical and histopathological correlation is needed for diagnosis of papulosquamous skin lesions. Periodic Acid Schiff show basement membrane thickening with focal fragmentation in lichen planus cases. Periodic Acid Schiff was performed in 36 cases of clinically suspected lichen planus cases. In this 24 cases showed PAS positivity. 12 cases were PAS negative. PAS stain is helpful in differentiating lichen planus from lichenoid reaction Periodic Acid Schiff show 67% positivity for lichen planus. PAS increased the positive correlation in lichen planus by 11%. Chi square test performed. The p value is <0.05 which shows statistically significant correlation. Hence periodic acid can be applied to enhance the accuracy of diagnosing lichen planus.

Item Type: Thesis (Masters)
Additional Information: Reg.No.: 201513256
Uncontrolled Keywords: Papulosquamous skin lesions ; Periodis acid Schiff ; basement membrane thickening ; basement membrane fragmentation ; lichen planus.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 19 Aug 2018 03:21
Last Modified: 19 Aug 2018 03:21
URI: http://repository-tnmgrmu.ac.in/id/eprint/9305

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