Study on insulin resistance in normal weight individuals – hospital based cross sectional descriptive study

Mariya, A (2018) Study on insulin resistance in normal weight individuals – hospital based cross sectional descriptive study. Masters thesis, Thanjavur Medical College, Thanjavur.


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BACKGROUND: Insulin resistance and metabolic syndrome can be found even in individuals with normal weight defined by BMI. OBJECTIVE: To study the prevalence of Insulin resistance using HOMA index and metabolic syndrome in normal weight individuals and also to study the usefulness of Triglyceride glucose index in identifying insulin resistance among normal weight individuals. METHODS AND MATERIALS: Clinical parameters, Insulin levels and other biochemical parameters were measured in 220 subjects (normal weight individuals based on BMI) in both sex aged 21-50 years. JIS criteria was implemented for defining clinical and biochemical parameters. HOMA index and Triglyceride glucose index was assessed using Fasting blood sugar, Insulin level and triglyceride levels. The correlation of insulin resistance and metabolic syndrome and its prevalence were analyzed. RESULTS: The prevalence of Metabolic syndrome according to JIS definition was 25% in males (95% CI 16.8%-35.5%) and 47% in females (95%CI 39.06%-55.3%). The prevalence of Insulin resistance (HOMA-IR) was 7.5% in males (95% CI 3.5%-15.4%) and 8.6% in females (95%CI 5.0%-14.3%). The Mean Weight, Height, Waist circumference, Waist-Hip ratio, Skinfold thickness were significantly higher among men when compared with women whereas the skinfold thickness was significantly higher among women than men. HDL cholesterol was negatively correlated with HOMA index in both gender and was statistically significant. There was no statistically significant correlation between TyG index with clinical and biochemical parameters. CONCLUSION: In conclusion our study provides evidence for prevalence of Insulin resistance and Metabolic syndrome in normal weight individuals. There was no evidence for using trigyceride index to identify metabolically risky group among normal weight population. Considering these observations it has been proved that having a normal BMI doesn’t mean no risk for metabolic disorders and consequently for CVD. This situation reveals the need for change in routine screening of obese individuals defined by BMI alone and requires the incorporation of other clinical and biochemical parameters. There is a need for comprehensive studies addressing the complex interaction between fat content, distribution and activity, and muscle mass , and their effect on metabolism, CVD risk and survival.

Item Type: Thesis (Masters)
Additional Information: Reg. No.: 201511206
Uncontrolled Keywords: Insulin resistance ; Metabolic syndrome ; Normal weight individuals ; HOMA index ; Triglceride glucose index.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 08 Aug 2018 17:03
Last Modified: 09 Aug 2018 02:37

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