Aswin, S Krishna (2018) A study on incidence of rhabdomyolysis in liver cirrhosis and their correlation with serum albumin. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: Cirrhosis is an irreversible disorder of liver affecting it's architecture and function. Rhabdomyolysis is a consequence of muscle lysis leading to elevation of creatinine kinase. In this study we try to correlate the relationship of rhabdomyolysis in cirrhosis and it's correlation with albumin and renal failure METHODS: In this study we take cirrhotic patients who are confirmed by carotid doppler and staged clinically. patients are categorised by age sex and blood parameters like whole blood count, creatinine kinase, albumin and creatinine are collected. The above parameters are tabulated and statistically analysed by ANOVA. RESULTS: There is incidence of rhabdomyolysis among the patients with cirrhosis. The incidence of rhabdomyolysis is higher among the patients in stage 4 cirrhosis. But on comparing the relationship of cirrhosis with rhabdomyolysis, it was found that the correlation is weak and they are statistically insignificant. SUMMARY: There is reported cases of rhabdomyolysis in cirrhosis but the correlation was found to be weak. More studies have to be conducted to find the significance of rhabdomyolysis in cirrhosis and it's correlation with albumin and renal failure. CONCLUSION: The end points of our study are: •Rhabdomyolysis is seen in patients suffering from liver cirrhosis. •The correlation between rhabdomyolysis and liver cirrhosis are weak and statistically not significant. • In our study, rhabdomyolysis was seen more common in males. • In our study, rhabdomyolysis was more common inn more than 60 years age group. • In our study, rhabdomyolysis was more common in stage 4 disease. • The correlation between CPK and Albumin; CPK and Creatinine are weak and statistically not significant.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Cirrhosis ; rhabdomyolysis ; albumin ; renal failure. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 08 Aug 2018 15:55 |
| Last Modified: | 08 Aug 2018 15:55 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/9170 |
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