The study of the expression of muc-1 in gastric carcinomas and its correlation with the clinico-pathological variables

Anitha Chellam, A (2016) The study of the expression of muc-1 in gastric carcinomas and its correlation with the clinico-pathological variables. Masters thesis, Madras Medical College, Chennai.

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Abstract

Worldwide, Gastric cancer is the second most common type of cancer. Of the gastric cancer, adenocarcinoma is the most common malignancy. It comprises over 90% of all gastric cancers. Gastric mucins are synthesized by gastric epithelial cells which are cytoprotective. Mucins are glycoprotein with high molecular weight, which are membrane bound or secreted products synthesized by secretory epithelial cells. Mucins in general are classified as neutral and acidic. Normal gastric mucin is of neutral type. In neoplastic transformation of gastric mucosa, the neutral mucin production is decreased.. More than 15 mucin genes have been identified. MUC-1 expressed in tumor may function as an anti-adhesion molecule that inhibits cell to cell adhesion, inducing the release of cells from the tumor. In these manners MUC-1 expression may be associated with invasive or metastatic properties of tumor cells, resulting in poor prognosis for patients with gastric carcinoma showing MUC-1 expression. In the study period of 2 years from June 2013-June 2015, Gastric cancer had a peak incidence in the age group of 51 – 60 years, with the mean age of 55.5 years with 70% - in males and 30% in females. Males predominate in the ratio of 2 .3 : 1 . On immunohistochemistry with MUC1,the expression was membranous / cytoplasmic positivity (graded as 1+, 2+, 3+, Negative) which was seen in 64% of cases. An increase in expression of MUC1 positivity was seen with increasing age and intestinal type of gastric adenocarcinomas.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Gastric Adenocarcinoma ; Anti-adhesion ; MUC1 Expression ; Cytoplasmic.
Subjects: MEDICAL > Pathology
Depositing User: Laksham S
Date Deposited: 04 Jul 2017 12:04
Last Modified: 06 Nov 2018 19:41
URI: http://repository-tnmgrmu.ac.in/id/eprint/898

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