Koti. Krishna Amulya, (2018) To study the role of Diffusion weighted MRI imaging in predicting the response to concurrent chemoradiotherapy in patients with nasopharyngeal malignancies. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVE: To prospectively evaluate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in predicting the response to concurrent chemoradiotherapy in patients with nasopharyngeal malignancies. MATERIALS AND METHODS: Thirteen patients with Non-metastatic carcinoma nasopharynx underwent DWI-MRI before the start of chemoradiation (Pre-RT), one week after start of chemoradiation and at 4-6 weeks follow up. Mean and minimum ADC measurements were recorded for a given region by drawing regions of interest (ROIs) on the ADC map. Statistical analysis was done using SPSS. The difference between complete response and partial responders was assessed by Mann Whitney U test. ROC analysis was done to calculate predictive value of ADC as a biomarker. RESULTS: An increase in ADC was observed at each stage of therapy in the primary site and nodes. The difference in ADC values from Pre-RT to follow up was higher in complete responders than partial responders (p=.003). The baseline ADC were higher in complete responder than partial responder. We conclude that serial DWI-MRI is a potential tool for response prediction in carcinoma nasopharynx treated with chemoradiotherapy. This study needs to be continued and a larger sample size and long term follow up may help in establishing its role in clinical practice.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Diffusion-weighted MRI ; ADC values ; Carcinoma nasopharynx ; Response prediction. |
| Subjects: | MEDICAL > Radio Therapy |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Jul 2018 17:25 |
| Last Modified: | 21 Jul 2018 17:25 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8965 |
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