Lakshmi, S Subedar (2018) Elevated Blood Eosinophils and serum IgE levels as biomarkers in prediction of COPD exacerbation. Masters thesis, Stanley Medical College, Chennai.
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Abstract
BACKGROUND: Airway eosinophilia, hallmark feature of Asthma, is now a recognized inflammatory pattern in COPD. In 10–40% of COPD, eosinophilic airway inflammation has been reported. Smoking (nicotine), a risk factor promotes allergic reactions which cause elevated IgE levels. OBJECTIVES: 1. To identify COPD exacerbations associated with elevated blood eosinophils. 2. To correlate elevated blood eosinophils and serum IgE levels with exacerbation of COPD. METHODOLOGY: 140 COPD patients were studied prospectively for a period of 1 year (Aug 2016 to Aug 2017) in GHTM, Tambaram. Patients with clinical diagnosis of COPD and post-bronchodilator FEV1/FVC ratio of less than 0.7 as per GOLD criteria considered. Based on ANTHONISEN’S criteria classified as stable COPD & COPD exacerbation. Peripheral blood collected for Absolute Eosinophil Count (AEC) & Serum IgE. RESULTS: Among 140 COPD patients, Males-119 (85%), Females-21 (15%) were between 45-75 years of age group. COPD population belonging to GOLD I, GOLD II, GOLD III, GOLD IV staging were 21 (15%), 40(28.5%), 58 (41.4%), 21(15%) respectively. Of which, stable COPD were 53 (37.8%) & COPD exacerbations 87 (62%). The AEC in stable COPD (468.9) & COPD exacerbation (890.8) while, Serum IgE in stable COPD (1289.5) & COPD exacerbation (2309) was observed. Current smokers showed elevated AEC (747) & Serum IgE levels (2214) compared to nonsmokers with AEC (660) & Serum IgE (646) respectively. CONCLUSION: AEC & Serum IgE levels can be considered as biomarkers of COPD exacerbations that allow identification of patients who most likely respond to ICS.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Absolute eosinophil count ; serum IgE ; COPD ; smoking. |
| Subjects: | MEDICAL > Tuberculosis and Respiratory Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 20 Jul 2018 17:07 |
| Last Modified: | 25 Nov 2018 04:45 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8931 |
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