Changes in Mucociliary clearance and Olfaction following endoscopic sinus surgery

Vidya, H (2018) Changes in Mucociliary clearance and Olfaction following endoscopic sinus surgery. Masters thesis, Christian Medical College, Vellore.


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OBJECTIVES: 1. To study the changes in mucociliary clearance in patient with chronic rhinosinusitis following endoscopic sinus surgery. 2. To compare the preoperative and postoperative olfactory function following endoscopic sinus surgery in patients with chronic rhinosinusitis. METHODS: This study was a prospective observational trial evaluating the change in mucociliary clearance of the nose and paranasal sinus and olfaction following functional endoscopic sinus surgery in patients diagnosed to have chronic rhinosinusitis (CRS) with or without nasal polyps in the department of ENT in a tertiary hospital over a period of seven months. A preoperative saccharine time( ST) and olfactory function assessment using CCCRC test for all patients. After the surgery, patients were followed up from 3-6 months and tests were repeated at follow up. The changes in saccharine time and olfactory scores were calculated. RESULTS: A total of 96 patients with CRS were recruited and 68 were followed up. 66% of patients had polyposis and 80% had primary surgery. There was a statistically significant reduction of 26% in mucociliary clearance time (p value 0.01) and 10% improvement of olfactory scores(p <0.05) at follow up. The improvement in mucociliary time was more for patients with polyposis and for those who underwent revision surgery. Majority of patients with anosmia improved to hyposmia in the post operative period although hyposmic patients did not have any significant improvement. CONCLUSION: Through this study we would like to highlight the fact that Functional endoscopic sinus surgery apart from clearing the disease from the sinuses, improves the normal physiological functions of nose that are impaired due to the chronic inflammatory process. We were able to objectively assess two important aspects of nasal mucosa namely mucociliary clearance and olfaction. Our study showed that there is a significant improvement in nasal mucociliary clearance and olfaction after endoscopic sinus surgery. This holds good for the two groups of Chronic sinusitis – with or without polyposis and well as for primary and revision surgeries. The improvement in mucociliary clearance was more in patient who underwent revision surgery than primary surgery. Therefore one can expect a substantial improvementin nasal function in spite of performing a revision surgery. We can also conclude from our results that even in patients with extensive disease there is significant improvement in post operative mucociliary clearance and olfaction suggesting that burden of disease has no effect in the successful outcome of FESS.

Item Type: Thesis (Masters)
Additional Information: Reg.No: 221614356
Uncontrolled Keywords: Mucociliary clearance ; Olfaction ; endoscopic sinus surgery.
Subjects: MEDICAL > Otolaryngology
Depositing User: Subramani R
Date Deposited: 15 Jul 2018 09:52
Last Modified: 15 Jul 2018 09:52

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