Pachaiyappan, P (2010) Significance of coronary artery calcium scoring in patients with obstructive and non-obstructive coronary artery disease following stemi. Masters thesis, Madras Medical College, Chennai.
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Abstract
Coronary artery calcification (CAC) occurs in small amounts in the early lesions of atherosclerosis that appear in the second and third decades of life, but it is found more frequently in advanced lesions and in older age. C o r o n ary arterial calcification is part of the development of atherosclerosis, occurs almost exclusively in atherosclerotic arteries, and is absent in the normal vessel wall A positive CT study (defined as presence of any CAC) is nearly 100% specific for atheromatous coronary plaque. Since both obstructive and nonobstructive lesions can have calcification present in the intima, CAC is not specific for obstructive coronary disease. The site and the amount of coronary artery calcium and the percent of coronary luminal narrowing at the same anatomic site, the relation is nonlinear and has large confidence limits. As the occurrence of calcification reflects an advanced stage of plaque development, some researchers have proposed that the correlation between coronary calcification and acute coronary events may be suboptimal based largely on angiographic series5. In order to understand this apparent conflict between the stability of a calcified lesion and CHD event rates, one must recognize the association between atherosclerotic plaque extent and more frequent calcified and noncalcified plaque. That is, patients who have calcified plaque are also more likely to have non-calcified or "soft" plaque that is prone to rupture and acute coronary thrombosis. AIM OF THE STUDY: To compare CAC (coronary artery calcium) score in patients with Obstructive and Non obstructive CAD. To compare CAC score in patients with single and multivessel disease. To compare CAC score in males and females. To compare CAC score in those with and without HT, Smoking and Diabetes. To compare CAC score between IRA and other vessels in multivessel disease. CONCLUSION: 1) Sixty four slice MDCT derived CAC score is a useful tool to assess angiographic severity in Post MI population. 2) CAC scores showed good correlation in patients with obstructive CAD especially in Elderly, Diabetics and in those with a family history of CAD. 3) There is less correlation of CAC score with regards to other conventional risk factors like Gender, Hypertension and Smoking in both obstructive and non obstructive CAD. 4) CAC score was not useful to identity infarct related artery. 5) There was no linear correlation between CAC score and the number of vessel involvement. 6) There was a significant negative correlation in hypertensive patients among non obstructive CAD population.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Significance ; coronary artery calcium scoring ; patients ; obstructive ; non-obstructive coronary artery disease ; stemi. |
| Subjects: | MEDICAL > Cardiology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 04 Jul 2017 03:52 |
| Last Modified: | 04 Jul 2017 06:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/877 |
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