Balachandran, R (2018) Efficacy of platelet rich fibrin in combination with biphasic calcium phosphate in fracture healing. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.
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Abstract
INTRODUCTION: 11% of the world’s disease burden is caused by fractures and is predicted to be the major cause of death and disability in the future. The combination of biphasic calcium phosphate (BCP) with platelet rich fibrin (PRF) is a therapeutic alternative and it improves the pre-existing grafting materials available. The study was conducted to prove the efficacy of PRF + BCP in fracture healing process. This study’s aim was to compare the efficacy of platelet rich fibrin in combination with biphasic calcium phosphate in early callus formation. MATERIALS AND METHODS: A total of 26 patients participated in this study. They were divided into two groups, Group A (Study group) patients with upper limb diaphyseal fractures underwent open reduction and internal fixation with application of PRF + BCP over the fracture site which was compared with a control group where the patients received only current standard of care. Post operatively fracture healing was assessed using X rays. X rays were taken every month and the time taken for appearance of callus in the X rays were considered to be the beginning of fracture healing process. If the healing does not occur till 5 months, it will be considered to be non-union. RESULTS: 76.9% of the patients who received PRF+BCP showed callus formation within the sixth week, whereas only 38.5% of the controls showed callus formation during their twelfth week. It was found to be statistically significant (p<0.05). CONCLUSION: 92.3% of the cases showed callus formation in a period of less than 8 weeks whereas 46.2% of the controls showed callus formation only during their 12th week only. This shows that, PRF+BCP favours early callus formation and improves fracture healing process.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Biphasic calcium phosphate ; Platelet rich fibrin ; Callus formation ; Fracture healing ; Upper limb diaphyseal fractures. |
| Subjects: | MEDICAL > Orthopaedics |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Jul 2018 15:43 |
| Last Modified: | 14 Jul 2018 15:43 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/8765 |
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