Infections and immunomodulation on liver transplant patients

Meena, M (2018) Infections and immunomodulation on liver transplant patients. Masters thesis, Stanley Medical College, Chennai.


Download (3MB) | Preview

Download (87kB) | Preview


INTRODUCTION: Liver Transplantation is a standard life saving procedure for many end stage liver diseases. Survival rate after liver transplantation has improved over the years, due to advances in surgical techniques and a reduction in allograft rejection produced by new potent immunosuppressive agents. The infections may be acquired, reactivation of latent infection in the recipient, donor transmitted diseases and nosocomial. The incidence of infection is found to be 80% and among them, the most common infection is bacterial (70%), followed by viral (20%) and fungal (8%) infection. AIM AND OBJECTIVES: To determine the common organisms that cause infections in liver transplant patients and the role of immune-suppressants in immunomodulation in liver transplant patients. MATERIALS AND METHODS: DONOR: Complete blood investigations, Throat swab c/s, Nasal swab c/s, Blood c/s & Urine c/s to rule out infections. RECIPIENT: Throat swab c/s, Nasal swab c/s, Blood c/s & Urine c/s before surgery to rule out infections. Symptomatic investigations are done daily and biochemical tests include, Complete blood investigations, Liver function test, Renal function test, Coagulation profile, Serum pro-calcitonin, Tacrolimus or Cyclosporine assay were done. RESULTS: The bacterial infections are more common after liver transplantation. It is caused by both gram negative and gram positive bacteria with predominance for gram negative organisms. The incidence of drug resistance is more common among these organisms. CONCLUSIONS: Bacterial infections are the major targets to overcome during the first 2 months after transplantation. During this period, controllable factors such as renal function preservation, glucose control, acute rejection prevention and early removal of indewelling catheters should be done.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Bacterial infections, Immunosuppressants, Tacrolimus assay, Acute graft rejection.
Subjects: MEDICAL > Microbiology
Depositing User: Subramani R
Date Deposited: 12 Jul 2018 17:18
Last Modified: 12 Jul 2018 17:18

Actions (login required)

View Item View Item