Study of Wayne's diagnostic criteria in hyperthyroidism

Shalikh Moidu, - (2014) Study of Wayne's diagnostic criteria in hyperthyroidism. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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INTRODUCTION: Thyroid gland is very important for metabolism of the body, its function is very important from in utero to maturation. . Fluctuation in levels of thyroid hormone from normal have far reaching effects on body’s homeostatic mechanism. The burden of thyroid related disease in the general population is vast. Thyroid related diseases are the most common among all endocrine diseases in India. In many studies conducted abroad ,half the people in a population has microscopic nodules, less than 15% have thyroid swellings, less than 3.5% are subclinically having occult papillary carcinoma, 10% have aberrant TSH levels and 5% have clinically significant hypothyroidism or hyperthyroidism. In spite of the successful coverage of National iodine deficiency diseases control programme (NIDDCP) in India, iodine deficiency is still prevalent in many parts throughout India. A retrospective cohort study of 325 cases of hyperthyroidism undergone surgery showed that, in more than 180 patients where Graves’ disease was the primary etiology followed by more than 100 cases of toxic multinodular goitre and more than 30 cases of (35) functioning nodules. AIMS OF STUDY: 1. To quantitavely analyse the accuracy of wayne’s clinical criteria in correlation of biochemical investigation. 2. To ascertain the commonest presenting signs and symptoms of hyperthyroidism in contest of the study. METHODOLOGY: Period of Study‐ September 2012 TO SEPTEMBER 2013 Sample Size: 53 Inclusion and Exclusion Criteria: Inclusion criteria‐ patient with symptoms suggestive of hyperthyroidism or neck swelling admitted in tvmch over duration of one year is being considered for the study. Inclusion criteria: Age > 12 years, Previously diagnosed to be a case of thyroid, Patient with thyroid swelling. Exclusion criteria: Age <12, Known serior medical co‐morbidity, Pregnancy, Indicator considered in the study are those mentioned in the criteria. A through history, clinical examination and investigations are carried out. Outcome Measures: Wayne’s diagnostic criteria as an aid to diagnose hyperthyroidism. Its utility is explained by theclinical fatures. Statistical Analysis: The statistical analysis is done by using method of central tendency (mean median, mode), Chi‐square test and data packages. CONCLUSION: 1. Waynes criteria holds a good deal of diagnostic accuracy. So it is worth applying this criteria at PHC level, to diagnose and for early referral at higher centre, especially in women of reproductive age group detrimental effects of thyroid disorders on reproduction can be prevented. 2. Due to high sensitivity, speficificity, positive predictive value and negative predictive value, wayne’s criteria proves basic clinical methods still holds good despite advanced diagnostic modalities. 3. Inter observer variation is an important limiting factor for waynes criteria, therefore, as score can vary with the observer. 4. Certain signs and symptoms are not included in wayne’s criteria which are not uncommonly encountered in hyperthyroid patients. 5. Early diagnosis in paediatric age group is of outmost importance as it can drastically change the outcome as role of thyroid hormones in development and maturation of all organ systems is well known.

Item Type: Thesis (Masters)
Uncontrolled Keywords: hyperthyroidism ; Wayne's diagnostic criteria.
Subjects: MEDICAL > General Surgery
Depositing User: Devi S
Date Deposited: 07 Jul 2018 01:53
Last Modified: 07 Jul 2018 01:53

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