Treatment of chronic venous ulcers with topical sucralfate: A prospective study

Sheryamsa, M (2014) Treatment of chronic venous ulcers with topical sucralfate: A prospective study. Masters thesis, Coimbatore Medical College, Coimbatore.


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Chronic venous ulcer is an important surgical condition due to high incidence and lack of standard therapeutic protocols. The care of these is often palliative and mostly unsuccessful. A variety of medical therapies to influence wound repair and regeneration are currently being investigated. Topical drugs have shown promise in this regard. Wound healing is a complex process with angiogenesis, cell proliferation, inflammation and re-epithelialization. Thus the ideal drug to treat such ulcers should possess properties to enhance all these parameters. Sucralfate is a cytoprotective agent, which is used in treatment of GIT related diseases like peptic ulcers. Recent studies have shown the stimulating effect of sucralfate over EGF expression and other growth factors involved in tissue repair. Furthermore, the stimulating effects of sucralfate on vascular factors have been demonstrated. Several studies show that sucralfate increases wound contraction, re-epithelialization and diminishes inflammatory reactions. It is safe as demonstrated by complete lack of side effects. Multiple studies using sucralfate for treating epithelial wounds showed encouraging results and served as basis for conducting this study. 30 patients were randomized into study and control groups and treated with topical sucralfate and saline dressings respectively. Parametric analysis of decrease in ulcer size, granulation and decrease in pain over ulcer. Majority of the study group showed improvement in all parameters while that in control group was drastically low. The current study involved a small group of patients but showed promising results with decrease in objective and subjective symptoms. Sucralfate being an inexpensive drug lessens the need for heavy expenditure. We conclude that sucralfate can be one such alternative solution to this age old problem and deserves thorough research, exploration and evaluation in this regard.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Chronic venous ulcer ; sucralfate topical application ; wound healing ; epithelial wounds.
Subjects: MEDICAL > General Surgery
Depositing User: Devi S
Date Deposited: 06 Jul 2018 16:26
Last Modified: 07 Jul 2018 17:34

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