Hormone receptor status in breast cancer in relation to histological grading, age and lymph node involvement

Rani Suganya, R (2014) Hormone receptor status in breast cancer in relation to histological grading, age and lymph node involvement. Masters thesis, Stanley Medical College, Chennai.


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BACKGROUND: Aim of the study is to evaluate hormone receptor status and HER 2/neu in breast carcinoma by using immunohistochemical method and to correlate with histological grade, age and lymphnode involvement in breast cancer patients attending General Surgery OPD, Govt. Stanley Medical College Hospital, Chennai. AIMS AND OBJECTIVES: 1. To evaluate ER, PR receptor status and HER 2/neu oncoprotein expression in carcinoma breast using immunohistochemical method. 2. To evaluate tumour grading, lymph node status in histopathological specimen. 3. To correlate ER, PR and HER 2/neu status with lymph node, tumour grading and age of the patient. 4. To evaluate occurrence of histological variants of carcinoma breast in patients attending OPD in Govt. Stanley Medical College Hospital. MATERIALS AND METHODS: This is an analytical study done during the period from January 2013 to October 2013. It is conducted to female patients presented with a breast lump in the female OPD, The department of General surgery, Govt. Stanley Hospital, Chennai. Female patients with palpable lump are admitted and are subjected to detailed history regarding age, parity, family history, socio economic status, menstrual history, lactational history and any previous biopsy reports if any. Newly diagnosed patients and with unilateral breast malignancies, with no history of neoadjuvant chemotherapy are included in this study. Patients with bilateral breast malignancies and has a history of neoadjuvant chemotheroy are excluded from this study. Based on the clinical examination, patients are subjected to mammogram, fine needle aspiration cytology (FNAC). If FNAC is proven to be inconclusive, trucut biopsy was done. RESULTS: From the above study in a group of 50 breast cancer patients, we found that Invasive Ductal Carcinoma-Nos type constituted the most commonest histological variants. Regarding histological grade, Grade II tumours was found to be commonest. Estrogen and progesterone receptor positivity was found in about 70% of cases, whereas HER 2/neu positivity was found in 36% of the tumours. Larger the tumour size lesser is the expression of hormone receptor status. There is higher receptor expression in nodal negative patienrs.HER 2/neu overexpression is found in about 64% of nodal positive patients. Higher the histological grade lower the receptor positivity and greater the HER 2/neu overexpression. There is an inverse relation between the receptor and HER 2/neu overexpresssion. CONCLUSION: Estrogen, Progesterone receptor positive tumours are more common in the post menopausal women, tumours of more than 2cm in size, Histological grade I and in nodal negative patients. Oncoprotein overexpression is common among the tumours of more than 2cm in size, grade III tumours and in nodal positive patients. Hormone receptor and oncoprotein expression has an inverse correlation with each other.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Estrogen receptor ; Progesterone receptor ; HER 2/neu oncoprotein ; Grading ; Lymphnode ; Age.
Subjects: MEDICAL > General Surgery
Depositing User: Devi S
Date Deposited: 05 Jul 2018 03:44
Last Modified: 05 Jul 2018 17:18
URI: http://repository-tnmgrmu.ac.in/id/eprint/8636

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