A study on p00 revalance of Helicobacter pylori infection in gastroduodenal perforation

Abdul Maliq, M (2014) A study on p00 revalance of Helicobacter pylori infection in gastroduodenal perforation. Masters thesis, Madras Medical College, Chennai.


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AIM OF THE STUDY: To study the prevalence of helicobacter pylori infection in Gastroduodenal perforations in Rajiv Gandhi Government General Hospital, Chennai. METHODS: Prospective observational study. The study includes the patients admitted ,evaluated and diagnosed as Gastroduodenal perforation intra operatively. Biopsy was taken from the perforated ulcer site and adjacent mucosa, which was sent for Histopathological examination for Helicobacter Pylori detection by Giemsa staining. RESULTS: 50 patients presenting intra-operatively with Gastroduodenal perforation were studied for H.Pylori by histopathological examination. Of them, 44 (88%) patients were found to have duodenal perforation and 6 (12%) were found to have Gastric perforation. In the duodenal perforation group, 21 (42%) patients were found to be H. pylori positive. In the gastric perforation group, 1 (2%) patient was found to be H. pylori positive. CONCLUSION: 1. Gastroduodenal ulcer perforation still remains one of the most common cause of acute abdominal catastrophe, with male preponderance. 2. We conclude that H. pylori is an important factor in the etiology of gastroduodenal ulcer perforation and accounts for 44 % of the cases. (Duodenal perforation – 42%, Gasstric perforation – 2%) 3. In our study, we found that gastroduodenal ulcer perforation is a multifactorial disease with alcohol (64%), smoking (48%) and NSAIDs (22%) being common causative factors. 4. Hence we conclude that , H.Pylori is one of the causative factor for the Gastroduodenal perforation.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Gastroduodenal perforations ; Helicobacter pylori.
Subjects: MEDICAL > General Surgery
Depositing User: Devi S
Date Deposited: 24 Jun 2018 17:01
Last Modified: 24 Jun 2018 17:01
URI: http://repository-tnmgrmu.ac.in/id/eprint/8604

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